Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea

Abstract Increasing evidence suggests that obstructive sleep apnea (OSA) is a metabolic syndrome-related disease; however, the association between nonalcoholic fatty liver disease (NAFLD) and OSA is not firmly established. In this study, we investigated the relationship between NAFLD and OSA in a ge...

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Autores principales:	Goh Eun Chung, Eun Ju Cho, Jeong-Ju Yoo, Young Chang, Yuri Cho, Sang-Hyun Park, Dong Wook Shin, Kyungdo Han, Su Jong Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d18a36b56604214993396d0aece0608
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spelling	oai:doaj.org-article:8d18a36b56604214993396d0aece06082021-12-02T14:33:51ZNonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea10.1038/s41598-021-92703-02045-2322https://doaj.org/article/8d18a36b56604214993396d0aece06082021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92703-0https://doaj.org/toc/2045-2322Abstract Increasing evidence suggests that obstructive sleep apnea (OSA) is a metabolic syndrome-related disease; however, the association between nonalcoholic fatty liver disease (NAFLD) and OSA is not firmly established. In this study, we investigated the relationship between NAFLD and OSA in a general population drawn from a nationwide population-based cohort. Data from the Korean National Health Insurance System between January 2009 and December 2009 were analyzed using Cox proportional hazards model. NAFLD was defined as a fatty liver index (FLI) ≥ 60 in patients without excessive alcohol consumption (who were excluded from the study). Newly diagnosed OSA during follow-up was identified using claims data. Among the 8,116,524 participants, 22.6% had an FLI score of 30–60 and 11.5% had an FLI ≥ 60. During median follow-up of 6.3 years, 45,143 cases of incident OSA occurred. In multivariable analysis, the risk of OSA was significantly higher in the higher FLI groups (adjusted hazard ratio [aHR] 1.15, 95% confidence interval [CI] 1.12–1.18 for FLI 30–60 and aHR 1.21, 95% CI 1.17–1.26 for FLI ≥ 60). These findings were consistent regardless of body mass index and presence of abdominal obesity. In conclusion, a high FLI score may help identify individuals with a high risk of OSA. Understanding the association between NAFLD and OSA may have clinical implications for risk-stratification of individuals with NAFLD.Goh Eun ChungEun Ju ChoJeong-Ju YooYoung ChangYuri ChoSang-Hyun ParkDong Wook ShinKyungdo HanSu Jong YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Goh Eun Chung Eun Ju Cho Jeong-Ju Yoo Young Chang Yuri Cho Sang-Hyun Park Dong Wook Shin Kyungdo Han Su Jong Yu Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
description	Abstract Increasing evidence suggests that obstructive sleep apnea (OSA) is a metabolic syndrome-related disease; however, the association between nonalcoholic fatty liver disease (NAFLD) and OSA is not firmly established. In this study, we investigated the relationship between NAFLD and OSA in a general population drawn from a nationwide population-based cohort. Data from the Korean National Health Insurance System between January 2009 and December 2009 were analyzed using Cox proportional hazards model. NAFLD was defined as a fatty liver index (FLI) ≥ 60 in patients without excessive alcohol consumption (who were excluded from the study). Newly diagnosed OSA during follow-up was identified using claims data. Among the 8,116,524 participants, 22.6% had an FLI score of 30–60 and 11.5% had an FLI ≥ 60. During median follow-up of 6.3 years, 45,143 cases of incident OSA occurred. In multivariable analysis, the risk of OSA was significantly higher in the higher FLI groups (adjusted hazard ratio [aHR] 1.15, 95% confidence interval [CI] 1.12–1.18 for FLI 30–60 and aHR 1.21, 95% CI 1.17–1.26 for FLI ≥ 60). These findings were consistent regardless of body mass index and presence of abdominal obesity. In conclusion, a high FLI score may help identify individuals with a high risk of OSA. Understanding the association between NAFLD and OSA may have clinical implications for risk-stratification of individuals with NAFLD.
format	article
author	Goh Eun Chung Eun Ju Cho Jeong-Ju Yoo Young Chang Yuri Cho Sang-Hyun Park Dong Wook Shin Kyungdo Han Su Jong Yu
author_facet	Goh Eun Chung Eun Ju Cho Jeong-Ju Yoo Young Chang Yuri Cho Sang-Hyun Park Dong Wook Shin Kyungdo Han Su Jong Yu
author_sort	Goh Eun Chung
title	Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
title_short	Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
title_full	Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
title_fullStr	Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
title_full_unstemmed	Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
title_sort	nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d18a36b56604214993396d0aece0608
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Nonalcoholic fatty liver disease is associated with the development of obstructive sleep apnea

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