Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults

Abstract Gene–diet interactions may play an important role in the inter individual diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in alterin...

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Autores principales:	Faezeh Abaj, Masoumeh Rafiee, Fariba Koohdani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d1aa793fa3b473e9bfec1618111f563
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spelling	oai:doaj.org-article:8d1aa793fa3b473e9bfec1618111f5632021-12-02T14:53:42ZInteraction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults10.1038/s41598-021-95359-y2045-2322https://doaj.org/article/8d1aa793fa3b473e9bfec1618111f5632021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95359-yhttps://doaj.org/toc/2045-2322Abstract Gene–diet interactions may play an important role in the inter individual diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in altering on CVD risk factors among type 2 diabetes mellitus (T2DM). In this cross-sectional study, blood samples were collected from 220 type 2 diabetic patients (134 females and 86 male) with a mean age of 52.24 years in Tehran, Iran. DIL and DII were obtained via validated food-frequency questionnaire (FFQ). Taq1B polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin and ghrelin were measured by standard protocol. Patients with B1B1 genotype had lower lipid profiles include LDL/HDL (P < 0.001) and TG (P = 0.04) when they consumed diets higher on the DIL and DII index. Moreover, carriers of B2B2 genotype who were in the last tertile of DIL had higher antioxidant and inflammatory markers include SOD (P = 0.01), PGF2α (P = 0.04) and CRP (P = 0.02). Further, a significant interaction between CETP TaqB1 and DII was shown in terms of WC (P = 0.01), where the highest WC were observed in B2B2 genotype carriers following a DII score. However, the highest inflammatory and antioxidant markers include CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02) were observed in B2B2 genotype carriers when they consumed diets higher on the DII index. Based on the current study, it could be proposed that CETP polymorphism may be associated with CVD risk factors in T2DM patients with high following insulin indices, including DII and DIL. It seems that CETP Taq1B polymorphism can invert the result produced by insulin. This conclusion illustrates that the CETP Taq1B B1 allele could counteract the CVD risk induced by high DII and DIL.Faezeh AbajMasoumeh RafieeFariba KoohdaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Faezeh Abaj Masoumeh Rafiee Fariba Koohdani Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
description	Abstract Gene–diet interactions may play an important role in the inter individual diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in altering on CVD risk factors among type 2 diabetes mellitus (T2DM). In this cross-sectional study, blood samples were collected from 220 type 2 diabetic patients (134 females and 86 male) with a mean age of 52.24 years in Tehran, Iran. DIL and DII were obtained via validated food-frequency questionnaire (FFQ). Taq1B polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin and ghrelin were measured by standard protocol. Patients with B1B1 genotype had lower lipid profiles include LDL/HDL (P < 0.001) and TG (P = 0.04) when they consumed diets higher on the DIL and DII index. Moreover, carriers of B2B2 genotype who were in the last tertile of DIL had higher antioxidant and inflammatory markers include SOD (P = 0.01), PGF2α (P = 0.04) and CRP (P = 0.02). Further, a significant interaction between CETP TaqB1 and DII was shown in terms of WC (P = 0.01), where the highest WC were observed in B2B2 genotype carriers following a DII score. However, the highest inflammatory and antioxidant markers include CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02) were observed in B2B2 genotype carriers when they consumed diets higher on the DII index. Based on the current study, it could be proposed that CETP polymorphism may be associated with CVD risk factors in T2DM patients with high following insulin indices, including DII and DIL. It seems that CETP Taq1B polymorphism can invert the result produced by insulin. This conclusion illustrates that the CETP Taq1B B1 allele could counteract the CVD risk induced by high DII and DIL.
format	article
author	Faezeh Abaj Masoumeh Rafiee Fariba Koohdani
author_facet	Faezeh Abaj Masoumeh Rafiee Fariba Koohdani
author_sort	Faezeh Abaj
title	Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
title_short	Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
title_full	Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
title_fullStr	Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
title_full_unstemmed	Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
title_sort	interaction between cetp polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d1aa793fa3b473e9bfec1618111f563
work_keys_str_mv	AT faezehabaj interactionbetweencetppolymorphismanddietaryinsulinindexandloadinrelationtocardiovascularriskfactorsindiabeticadults AT masoumehrafiee interactionbetweencetppolymorphismanddietaryinsulinindexandloadinrelationtocardiovascularriskfactorsindiabeticadults AT faribakoohdani interactionbetweencetppolymorphismanddietaryinsulinindexandloadinrelationtocardiovascularriskfactorsindiabeticadults
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Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults

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