Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract

Danling Liu,1,* Tingting Qian,1,* Shan Sun,1 Jack J Jiang1,2 1Otorhinolaryngology Department, ENT Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai 200032, People’s Republic of Ch...

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Autores principales:	Liu D, Qian T, Sun S, Jiang JJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	laryngopharyngeal reflux (lpr) the upper aerodigestive tract (uat) inflammatory response mucosal barrier dysfunction Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8d1b8963e97a4a548f2b591c3795e9ca
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spelling	oai:doaj.org-article:8d1b8963e97a4a548f2b591c3795e9ca2021-12-02T15:15:25ZLaryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract1178-7031https://doaj.org/article/8d1b8963e97a4a548f2b591c3795e9ca2021-01-01T00:00:00Zhttps://www.dovepress.com/laryngopharyngeal-reflux-and-inflammatory-responses-in-mucosal-barrier-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Danling Liu,1,* Tingting Qian,1,* Shan Sun,1 Jack J Jiang1,2 1Otorhinolaryngology Department, ENT Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai 200032, People’s Republic of China; 2Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, WI 53792-7375, USA*These authors contributed equally to this workCorrespondence: Shan Sun Email Shansun@fudan.edu.cnJack J Jiang Email jjjiang@fudan.edu.cnAbstract: The upper aerodigestive tract (UAT) is the first line of defense against environmental stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular junctions, epithelial cells, and immune cells are the major constituents of this defensive mucosal barrier. Laryngopharyngeal reflux (LPR) is recognized as an independent risk factor for UAT mucosal disorders, and in this review, we describe the components and functions of the mucosal barrier and the results of LPR-induced mucosal inflammation in the UAT. We discuss the interactions between the refluxate and the mucosal components and the mechanisms through which these damaging events disrupt and alter the mucosal barriers. In addition, we discuss the dynamic alterations in the mucosal barrier that might be potential therapeutic targets for LPR-induced disorders.Keywords: laryngopharyngeal reflux, LPR, upper aerodigestive tract, UAT, inflammatory response, mucosal barrier dysfunctionLiu DQian TSun SJiang JJDove Medical Pressarticlelaryngopharyngeal reflux (lpr)the upper aerodigestive tract (uat)inflammatory responsemucosal barrier dysfunctionPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 1291-1304 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	laryngopharyngeal reflux (lpr) the upper aerodigestive tract (uat) inflammatory response mucosal barrier dysfunction Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	laryngopharyngeal reflux (lpr) the upper aerodigestive tract (uat) inflammatory response mucosal barrier dysfunction Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Liu D Qian T Sun S Jiang JJ Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
description	Danling Liu,1,* Tingting Qian,1,* Shan Sun,1 Jack J Jiang1,2 1Otorhinolaryngology Department, ENT Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai 200032, People’s Republic of China; 2Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, WI 53792-7375, USA*These authors contributed equally to this workCorrespondence: Shan Sun Email Shansun@fudan.edu.cnJack J Jiang Email jjjiang@fudan.edu.cnAbstract: The upper aerodigestive tract (UAT) is the first line of defense against environmental stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular junctions, epithelial cells, and immune cells are the major constituents of this defensive mucosal barrier. Laryngopharyngeal reflux (LPR) is recognized as an independent risk factor for UAT mucosal disorders, and in this review, we describe the components and functions of the mucosal barrier and the results of LPR-induced mucosal inflammation in the UAT. We discuss the interactions between the refluxate and the mucosal components and the mechanisms through which these damaging events disrupt and alter the mucosal barriers. In addition, we discuss the dynamic alterations in the mucosal barrier that might be potential therapeutic targets for LPR-induced disorders.Keywords: laryngopharyngeal reflux, LPR, upper aerodigestive tract, UAT, inflammatory response, mucosal barrier dysfunction
format	article
author	Liu D Qian T Sun S Jiang JJ
author_facet	Liu D Qian T Sun S Jiang JJ
author_sort	Liu D
title	Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
title_short	Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
title_full	Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
title_fullStr	Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
title_full_unstemmed	Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
title_sort	laryngopharyngeal reflux and inflammatory responses in mucosal barrier dysfunction of the upper aerodigestive tract
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8d1b8963e97a4a548f2b591c3795e9ca
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Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract

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