The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-...

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Autores principales: Andrew C. Pawlowski, Peter J. Stogios, Kalinka Koteva, Tatiana Skarina, Elena Evdokimova, Alexei Savchenko, Gerard D. Wright
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8d1fd42155f34c23acbadc3b6245e7ca
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spelling oai:doaj.org-article:8d1fd42155f34c23acbadc3b6245e7ca2021-12-02T14:39:26ZThe evolution of substrate discrimination in macrolide antibiotic resistance enzymes10.1038/s41467-017-02680-02041-1723https://doaj.org/article/8d1fd42155f34c23acbadc3b6245e7ca2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02680-0https://doaj.org/toc/2041-1723New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.Andrew C. PawlowskiPeter J. StogiosKalinka KotevaTatiana SkarinaElena EvdokimovaAlexei SavchenkoGerard D. WrightNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andrew C. Pawlowski
Peter J. Stogios
Kalinka Koteva
Tatiana Skarina
Elena Evdokimova
Alexei Savchenko
Gerard D. Wright
The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
description New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutations that expand the substrate range of antibiotic-inactivating enzymes.
format article
author Andrew C. Pawlowski
Peter J. Stogios
Kalinka Koteva
Tatiana Skarina
Elena Evdokimova
Alexei Savchenko
Gerard D. Wright
author_facet Andrew C. Pawlowski
Peter J. Stogios
Kalinka Koteva
Tatiana Skarina
Elena Evdokimova
Alexei Savchenko
Gerard D. Wright
author_sort Andrew C. Pawlowski
title The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_short The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_full The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_fullStr The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_full_unstemmed The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
title_sort evolution of substrate discrimination in macrolide antibiotic resistance enzymes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8d1fd42155f34c23acbadc3b6245e7ca
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