Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties

Both gain-of-function of mutant p53 (GOF) and loss of wild-type p53 (LOH) are independently associated with cancer. Here, the authors show that LOH promotes GOF tumourigenesis by increasing tumor-initiating ability and metastasis.

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Autores principales:	Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Eri Sakai, Seong-Jin Kim, Masanobu Oshima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d1fffa592274a9e92de86ee38fb2d03
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spelling	oai:doaj.org-article:8d1fffa592274a9e92de86ee38fb2d032021-12-02T17:02:20ZLoss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties10.1038/s41467-020-16245-12041-1723https://doaj.org/article/8d1fffa592274a9e92de86ee38fb2d032020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16245-1https://doaj.org/toc/2041-1723Both gain-of-function of mutant p53 (GOF) and loss of wild-type p53 (LOH) are independently associated with cancer. Here, the authors show that LOH promotes GOF tumourigenesis by increasing tumor-initiating ability and metastasis.Mizuho NakayamaChang Pyo HongHiroko OshimaEri SakaiSeong-Jin KimMasanobu OshimaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mizuho Nakayama Chang Pyo Hong Hiroko Oshima Eri Sakai Seong-Jin Kim Masanobu Oshima Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
description	Both gain-of-function of mutant p53 (GOF) and loss of wild-type p53 (LOH) are independently associated with cancer. Here, the authors show that LOH promotes GOF tumourigenesis by increasing tumor-initiating ability and metastasis.
format	article
author	Mizuho Nakayama Chang Pyo Hong Hiroko Oshima Eri Sakai Seong-Jin Kim Masanobu Oshima
author_facet	Mizuho Nakayama Chang Pyo Hong Hiroko Oshima Eri Sakai Seong-Jin Kim Masanobu Oshima
author_sort	Mizuho Nakayama
title	Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
title_short	Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
title_full	Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
title_fullStr	Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
title_full_unstemmed	Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
title_sort	loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d1fffa592274a9e92de86ee38fb2d03
work_keys_str_mv	AT mizuhonakayama lossofwildtypep53promotesmutantp53drivenmetastasisthroughacquisitionofsurvivalandtumorinitiatingproperties AT changpyohong lossofwildtypep53promotesmutantp53drivenmetastasisthroughacquisitionofsurvivalandtumorinitiatingproperties AT hirokooshima lossofwildtypep53promotesmutantp53drivenmetastasisthroughacquisitionofsurvivalandtumorinitiatingproperties AT erisakai lossofwildtypep53promotesmutantp53drivenmetastasisthroughacquisitionofsurvivalandtumorinitiatingproperties AT seongjinkim lossofwildtypep53promotesmutantp53drivenmetastasisthroughacquisitionofsurvivalandtumorinitiatingproperties AT masanobuoshima lossofwildtypep53promotesmutantp53drivenmetastasisthroughacquisitionofsurvivalandtumorinitiatingproperties
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Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties

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