The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

Abstract The fundamental role of major, minor and trace elements in different physiological and pathological processes occurring in living organism makes that elemental analysis of biomedical samples becomes more and more popular issue. The most often used tools for analysis of the elemental composi...

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Autores principales:	Karolina Planeta, Aldona Kubala-Kukus, Agnieszka Drozdz, Katarzyna Matusiak, Zuzanna Setkowicz, Joanna Chwiej
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d2269da35434485a8210c0faf4c501d
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spelling	oai:doaj.org-article:8d2269da35434485a8210c0faf4c501d2021-12-02T13:30:22ZThe assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples10.1038/s41598-021-82179-32045-2322https://doaj.org/article/8d2269da35434485a8210c0faf4c501d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82179-3https://doaj.org/toc/2045-2322Abstract The fundamental role of major, minor and trace elements in different physiological and pathological processes occurring in living organism makes that elemental analysis of biomedical samples becomes more and more popular issue. The most often used tools for analysis of the elemental composition of biological samples include Flame and Graphite Furnace Atomic Absorption Spectroscopy (F-AAS and GF-AAS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Each of these techniques has many advantages and limitations that should be considered in the first stage of planning the measurement procedure. Their reliability can be checked in the validation process and the precision, trueness and detection limits of elements belong to the most frequently determined validation parameters. The main purpose of this paper was the discussion of selected instrumental techniques (F-AAS, GF-AAS, ICP-OES and ICP-MS) in term of the achieved validation parameters and the usefulness in the analysis of biological samples. The focus in the detailed literature studies was also put on the methods of preparation of the biomedical samples. What is more based on the own data the usefulness of the total reflection X-ray fluorescence spectroscopy for the elemental analysis of animal tissues was examined. The detection limits of elements, precision and trueness for the technique were determined and compared with the literature data concerning other of the discussed techniques of elemental analysis. Reassuming, the following paper is to serve as a guide and comprehensive source of information concerning the validation parameters achievable in different instrumental techniques used for the elemental analysis of biomedical samples.Karolina PlanetaAldona Kubala-KukusAgnieszka DrozdzKatarzyna MatusiakZuzanna SetkowiczJoanna ChwiejNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-31 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karolina Planeta Aldona Kubala-Kukus Agnieszka Drozdz Katarzyna Matusiak Zuzanna Setkowicz Joanna Chwiej The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
description	Abstract The fundamental role of major, minor and trace elements in different physiological and pathological processes occurring in living organism makes that elemental analysis of biomedical samples becomes more and more popular issue. The most often used tools for analysis of the elemental composition of biological samples include Flame and Graphite Furnace Atomic Absorption Spectroscopy (F-AAS and GF-AAS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Each of these techniques has many advantages and limitations that should be considered in the first stage of planning the measurement procedure. Their reliability can be checked in the validation process and the precision, trueness and detection limits of elements belong to the most frequently determined validation parameters. The main purpose of this paper was the discussion of selected instrumental techniques (F-AAS, GF-AAS, ICP-OES and ICP-MS) in term of the achieved validation parameters and the usefulness in the analysis of biological samples. The focus in the detailed literature studies was also put on the methods of preparation of the biomedical samples. What is more based on the own data the usefulness of the total reflection X-ray fluorescence spectroscopy for the elemental analysis of animal tissues was examined. The detection limits of elements, precision and trueness for the technique were determined and compared with the literature data concerning other of the discussed techniques of elemental analysis. Reassuming, the following paper is to serve as a guide and comprehensive source of information concerning the validation parameters achievable in different instrumental techniques used for the elemental analysis of biomedical samples.
format	article
author	Karolina Planeta Aldona Kubala-Kukus Agnieszka Drozdz Katarzyna Matusiak Zuzanna Setkowicz Joanna Chwiej
author_facet	Karolina Planeta Aldona Kubala-Kukus Agnieszka Drozdz Katarzyna Matusiak Zuzanna Setkowicz Joanna Chwiej
author_sort	Karolina Planeta
title	The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
title_short	The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
title_full	The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
title_fullStr	The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
title_full_unstemmed	The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
title_sort	assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d2269da35434485a8210c0faf4c501d
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The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

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