Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.

Mapping and decoding brain activity patterns underlying learning and memory represents both great interest and immense challenge. At present, very little is known regarding many of the very basic questions regarding the neural codes of memory: are fear memories retrieved during the freezing state or...

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Autores principales:	Hongmiao Zhang, Guifen Chen, Hui Kuang, Joe Z Tsien
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d2697cfba604646a0a015ef91e4ef35
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spelling	oai:doaj.org-article:8d2697cfba604646a0a015ef91e4ef352021-11-18T08:44:45ZMapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.1932-620310.1371/journal.pone.0079454https://doaj.org/article/8d2697cfba604646a0a015ef91e4ef352013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24302990/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Mapping and decoding brain activity patterns underlying learning and memory represents both great interest and immense challenge. At present, very little is known regarding many of the very basic questions regarding the neural codes of memory: are fear memories retrieved during the freezing state or non-freezing state of the animals? How do individual memory traces give arise to a holistic, real-time associative memory engram? How are memory codes regulated by synaptic plasticity? Here, by applying high-density electrode arrays and dimensionality-reduction decoding algorithms, we investigate hippocampal CA1 activity patterns of trace fear conditioning memory code in inducible NMDA receptor knockout mice and their control littermates. Our analyses showed that the conditioned tone (CS) and unconditioned foot-shock (US) can evoke hippocampal ensemble responses in control and mutant mice. Yet, temporal formats and contents of CA1 fear memory engrams differ significantly between the genotypes. The mutant mice with disabled NMDA receptor plasticity failed to generate CS-to-US or US-to-CS associative memory traces. Moreover, the mutant CA1 region lacked memory traces for "what at when" information that predicts the timing relationship between the conditioned tone and the foot shock. The degraded associative fear memory engram is further manifested in its lack of intertwined and alternating temporal association between CS and US memory traces that are characteristic to the holistic memory recall in the wild-type animals. Therefore, our study has decoded real-time memory contents, timing relationship between CS and US, and temporal organizing patterns of fear memory engrams and demonstrated how hippocampal memory codes are regulated by NMDA receptor synaptic plasticity.Hongmiao ZhangGuifen ChenHui KuangJoe Z TsienPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79454 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongmiao Zhang Guifen Chen Hui Kuang Joe Z Tsien Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.
description	Mapping and decoding brain activity patterns underlying learning and memory represents both great interest and immense challenge. At present, very little is known regarding many of the very basic questions regarding the neural codes of memory: are fear memories retrieved during the freezing state or non-freezing state of the animals? How do individual memory traces give arise to a holistic, real-time associative memory engram? How are memory codes regulated by synaptic plasticity? Here, by applying high-density electrode arrays and dimensionality-reduction decoding algorithms, we investigate hippocampal CA1 activity patterns of trace fear conditioning memory code in inducible NMDA receptor knockout mice and their control littermates. Our analyses showed that the conditioned tone (CS) and unconditioned foot-shock (US) can evoke hippocampal ensemble responses in control and mutant mice. Yet, temporal formats and contents of CA1 fear memory engrams differ significantly between the genotypes. The mutant mice with disabled NMDA receptor plasticity failed to generate CS-to-US or US-to-CS associative memory traces. Moreover, the mutant CA1 region lacked memory traces for "what at when" information that predicts the timing relationship between the conditioned tone and the foot shock. The degraded associative fear memory engram is further manifested in its lack of intertwined and alternating temporal association between CS and US memory traces that are characteristic to the holistic memory recall in the wild-type animals. Therefore, our study has decoded real-time memory contents, timing relationship between CS and US, and temporal organizing patterns of fear memory engrams and demonstrated how hippocampal memory codes are regulated by NMDA receptor synaptic plasticity.
format	article
author	Hongmiao Zhang Guifen Chen Hui Kuang Joe Z Tsien
author_facet	Hongmiao Zhang Guifen Chen Hui Kuang Joe Z Tsien
author_sort	Hongmiao Zhang
title	Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.
title_short	Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.
title_full	Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.
title_fullStr	Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.
title_full_unstemmed	Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.
title_sort	mapping and deciphering neural codes of nmda receptor-dependent fear memory engrams in the hippocampus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8d2697cfba604646a0a015ef91e4ef35
work_keys_str_mv	AT hongmiaozhang mappinganddecipheringneuralcodesofnmdareceptordependentfearmemoryengramsinthehippocampus AT guifenchen mappinganddecipheringneuralcodesofnmdareceptordependentfearmemoryengramsinthehippocampus AT huikuang mappinganddecipheringneuralcodesofnmdareceptordependentfearmemoryengramsinthehippocampus AT joeztsien mappinganddecipheringneuralcodesofnmdareceptordependentfearmemoryengramsinthehippocampus
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Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus.

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