Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.

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Autores principales:	Stamatis Papathanasiou, Styliani Markoulaki, Logan J. Blaine, Mitchell L. Leibowitz, Cheng-Zhong Zhang, Rudolf Jaenisch, David Pellman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d2a4609b9d444b99c1baa3c89646009
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spelling	oai:doaj.org-article:8d2a4609b9d444b99c1baa3c896460092021-12-02T16:56:44ZWhole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing10.1038/s41467-021-26097-y2041-1723https://doaj.org/article/8d2a4609b9d444b99c1baa3c896460092021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26097-yhttps://doaj.org/toc/2041-1723A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.Stamatis PapathanasiouStyliani MarkoulakiLogan J. BlaineMitchell L. LeibowitzCheng-Zhong ZhangRudolf JaenischDavid PellmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stamatis Papathanasiou Styliani Markoulaki Logan J. Blaine Mitchell L. Leibowitz Cheng-Zhong Zhang Rudolf Jaenisch David Pellman Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
description	A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.
format	article
author	Stamatis Papathanasiou Styliani Markoulaki Logan J. Blaine Mitchell L. Leibowitz Cheng-Zhong Zhang Rudolf Jaenisch David Pellman
author_facet	Stamatis Papathanasiou Styliani Markoulaki Logan J. Blaine Mitchell L. Leibowitz Cheng-Zhong Zhang Rudolf Jaenisch David Pellman
author_sort	Stamatis Papathanasiou
title	Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_short	Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_full	Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_fullStr	Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_full_unstemmed	Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
title_sort	whole chromosome loss and genomic instability in mouse embryos after crispr-cas9 genome editing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d2a4609b9d444b99c1baa3c89646009
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Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

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