Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

A possible undesired outcome of CRISPR-Cas9 germline editing is unwanted karyotype alterations. Here the authors track aberrations through three divisions of embryonic development following Cas9 editing.

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Autores principales: Stamatis Papathanasiou, Styliani Markoulaki, Logan J. Blaine, Mitchell L. Leibowitz, Cheng-Zhong Zhang, Rudolf Jaenisch, David Pellman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/8d2a4609b9d444b99c1baa3c89646009
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