Phylointeractomics reconstructs functional evolution of protein binding

Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study o...

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Autores principales:	Dennis Kappei, Marion Scheibe, Maciej Paszkowski-Rogacz, Alina Bluhm, Toni Ingolf Gossmann, Sabrina Dietz, Mario Dejung, Holger Herlyn, Frank Buchholz, Matthias Mann, Falk Butter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d2c6013e78f4544b5d7c1228b6c7357
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spelling	oai:doaj.org-article:8d2c6013e78f4544b5d7c1228b6c73572021-12-02T14:41:21ZPhylointeractomics reconstructs functional evolution of protein binding10.1038/ncomms143342041-1723https://doaj.org/article/8d2c6013e78f4544b5d7c1228b6c73572017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14334https://doaj.org/toc/2041-1723Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.Dennis KappeiMarion ScheibeMaciej Paszkowski-RogaczAlina BluhmToni Ingolf GossmannSabrina DietzMario DejungHolger HerlynFrank BuchholzMatthias MannFalk ButterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dennis Kappei Marion Scheibe Maciej Paszkowski-Rogacz Alina Bluhm Toni Ingolf Gossmann Sabrina Dietz Mario Dejung Holger Herlyn Frank Buchholz Matthias Mann Falk Butter Phylointeractomics reconstructs functional evolution of protein binding
description	Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elucidate protein functional evolution with a study of the shelterin complex evolution.
format	article
author	Dennis Kappei Marion Scheibe Maciej Paszkowski-Rogacz Alina Bluhm Toni Ingolf Gossmann Sabrina Dietz Mario Dejung Holger Herlyn Frank Buchholz Matthias Mann Falk Butter
author_facet	Dennis Kappei Marion Scheibe Maciej Paszkowski-Rogacz Alina Bluhm Toni Ingolf Gossmann Sabrina Dietz Mario Dejung Holger Herlyn Frank Buchholz Matthias Mann Falk Butter
author_sort	Dennis Kappei
title	Phylointeractomics reconstructs functional evolution of protein binding
title_short	Phylointeractomics reconstructs functional evolution of protein binding
title_full	Phylointeractomics reconstructs functional evolution of protein binding
title_fullStr	Phylointeractomics reconstructs functional evolution of protein binding
title_full_unstemmed	Phylointeractomics reconstructs functional evolution of protein binding
title_sort	phylointeractomics reconstructs functional evolution of protein binding
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8d2c6013e78f4544b5d7c1228b6c7357
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Phylointeractomics reconstructs functional evolution of protein binding

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