Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after radiotherapy and they show that DGKA inhibition af...

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Autores principales:	Christoph Weigel, Marlon R. Veldwijk, Christopher C. Oakes, Petra Seibold, Alla Slynko, David B. Liesenfeld, Mariona Rabionet, Sabrina A. Hanke, Frederik Wenz, Elena Sperk, Axel Benner, Christoph Rösli, Roger Sandhoff, Yassen Assenov, Christoph Plass, Carsten Herskind, Jenny Chang-Claude, Peter Schmezer, Odilia Popanda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d2cbcdc585d437387a5d8eedf91802c
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spelling	oai:doaj.org-article:8d2cbcdc585d437387a5d8eedf91802c2021-12-02T15:33:47ZEpigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis10.1038/ncomms108932041-1723https://doaj.org/article/8d2cbcdc585d437387a5d8eedf91802c2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10893https://doaj.org/toc/2041-1723Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after radiotherapy and they show that DGKA inhibition affects lipid homeostasis and reduces pro-fibrotic fibroblast activation.Christoph WeigelMarlon R. VeldwijkChristopher C. OakesPetra SeiboldAlla SlynkoDavid B. LiesenfeldMariona RabionetSabrina A. HankeFrederik WenzElena SperkAxel BennerChristoph RösliRoger SandhoffYassen AssenovChristoph PlassCarsten HerskindJenny Chang-ClaudePeter SchmezerOdilia PopandaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christoph Weigel Marlon R. Veldwijk Christopher C. Oakes Petra Seibold Alla Slynko David B. Liesenfeld Mariona Rabionet Sabrina A. Hanke Frederik Wenz Elena Sperk Axel Benner Christoph Rösli Roger Sandhoff Yassen Assenov Christoph Plass Carsten Herskind Jenny Chang-Claude Peter Schmezer Odilia Popanda Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
description	Radiotherapy can induce fibrosis in cancer patients, limiting its use in clinical settings. Here, the authors identify a differentially methylated enhancer of the lipid kinase DGKA in fibroblasts from breast cancer patients developing fibrosis after radiotherapy and they show that DGKA inhibition affects lipid homeostasis and reduces pro-fibrotic fibroblast activation.
format	article
author	Christoph Weigel Marlon R. Veldwijk Christopher C. Oakes Petra Seibold Alla Slynko David B. Liesenfeld Mariona Rabionet Sabrina A. Hanke Frederik Wenz Elena Sperk Axel Benner Christoph Rösli Roger Sandhoff Yassen Assenov Christoph Plass Carsten Herskind Jenny Chang-Claude Peter Schmezer Odilia Popanda
author_facet	Christoph Weigel Marlon R. Veldwijk Christopher C. Oakes Petra Seibold Alla Slynko David B. Liesenfeld Mariona Rabionet Sabrina A. Hanke Frederik Wenz Elena Sperk Axel Benner Christoph Rösli Roger Sandhoff Yassen Assenov Christoph Plass Carsten Herskind Jenny Chang-Claude Peter Schmezer Odilia Popanda
author_sort	Christoph Weigel
title	Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
title_short	Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
title_full	Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
title_fullStr	Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
title_full_unstemmed	Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
title_sort	epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8d2cbcdc585d437387a5d8eedf91802c
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Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

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