A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.

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Detalles Bibliográficos
Autores principales: Luke A. Yates, Ricardo J. Aramayo, Nilisha Pokhrel, Colleen C. Caldwell, Joshua A. Kaplan, Rajika L. Perera, Maria Spies, Edwin Antony, Xiaodong Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/8d342a9ef98841d4b568cbf8c3f546c6
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Sumario:Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.

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