A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.

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Autores principales: Luke A. Yates, Ricardo J. Aramayo, Nilisha Pokhrel, Colleen C. Caldwell, Joshua A. Kaplan, Rajika L. Perera, Maria Spies, Edwin Antony, Xiaodong Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8d342a9ef98841d4b568cbf8c3f546c6
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spelling oai:doaj.org-article:8d342a9ef98841d4b568cbf8c3f546c62021-12-02T15:34:00ZA structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA10.1038/s41467-018-07883-72041-1723https://doaj.org/article/8d342a9ef98841d4b568cbf8c3f546c62018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07883-7https://doaj.org/toc/2041-1723Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.Luke A. YatesRicardo J. AramayoNilisha PokhrelColleen C. CaldwellJoshua A. KaplanRajika L. PereraMaria SpiesEdwin AntonyXiaodong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Luke A. Yates
Ricardo J. Aramayo
Nilisha Pokhrel
Colleen C. Caldwell
Joshua A. Kaplan
Rajika L. Perera
Maria Spies
Edwin Antony
Xiaodong Zhang
A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA
description Replication Protein A (RPA) coats single stranded DNA (ssDNA) generated during DNA recombination, replication and repair. Here the authors present a structural model suggesting how RPA’s DNA-binding domains promote cooperative assembly of multiple RPAs on long ssDNA.
format article
author Luke A. Yates
Ricardo J. Aramayo
Nilisha Pokhrel
Colleen C. Caldwell
Joshua A. Kaplan
Rajika L. Perera
Maria Spies
Edwin Antony
Xiaodong Zhang
author_facet Luke A. Yates
Ricardo J. Aramayo
Nilisha Pokhrel
Colleen C. Caldwell
Joshua A. Kaplan
Rajika L. Perera
Maria Spies
Edwin Antony
Xiaodong Zhang
author_sort Luke A. Yates
title A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA
title_short A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA
title_full A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA
title_fullStr A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA
title_full_unstemmed A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA
title_sort structural and dynamic model for the assembly of replication protein a on single-stranded dna
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8d342a9ef98841d4b568cbf8c3f546c6
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