A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used tr...

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Autores principales:	Doris Kumadoh, Mary-Ann Archer, Genevieve N. Yeboah, Michael O. Kyene, Mavis Boakye-Yiadom, Ofosua Adi-Dako, Christina Osei-Asare, Emmanuel Adase, Alfred A. Appiah, Susana O. Mintah
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Peptic ulcer disease Herbal products Anti-ulcer activity Helicobacter pylori Enterica Dyspepsia Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/8d370449808048c5bb26bb95650846ef
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spelling	oai:doaj.org-article:8d370449808048c5bb26bb95650846ef2021-12-02T05:03:21ZA review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules2405-844010.1016/j.heliyon.2021.e08465https://doaj.org/article/8d370449808048c5bb26bb95650846ef2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021025688https://doaj.org/toc/2405-8440Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.Doris KumadohMary-Ann ArcherGenevieve N. YeboahMichael O. KyeneMavis Boakye-YiadomOfosua Adi-DakoChristina Osei-AsareEmmanuel AdaseAlfred A. AppiahSusana O. MintahElsevierarticlePeptic ulcer diseaseHerbal productsAnti-ulcer activityHelicobacter pyloriEntericaDyspepsiaScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 12, Pp e08465- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Peptic ulcer disease Herbal products Anti-ulcer activity Helicobacter pylori Enterica Dyspepsia Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Peptic ulcer disease Herbal products Anti-ulcer activity Helicobacter pylori Enterica Dyspepsia Science (General) Q1-390 Social sciences (General) H1-99 Doris Kumadoh Mary-Ann Archer Genevieve N. Yeboah Michael O. Kyene Mavis Boakye-Yiadom Ofosua Adi-Dako Christina Osei-Asare Emmanuel Adase Alfred A. Appiah Susana O. Mintah A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
description	Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. Methods: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. Results: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. Interpretation: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.
format	article
author	Doris Kumadoh Mary-Ann Archer Genevieve N. Yeboah Michael O. Kyene Mavis Boakye-Yiadom Ofosua Adi-Dako Christina Osei-Asare Emmanuel Adase Alfred A. Appiah Susana O. Mintah
author_facet	Doris Kumadoh Mary-Ann Archer Genevieve N. Yeboah Michael O. Kyene Mavis Boakye-Yiadom Ofosua Adi-Dako Christina Osei-Asare Emmanuel Adase Alfred A. Appiah Susana O. Mintah
author_sort	Doris Kumadoh
title	A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_short	A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_full	A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_fullStr	A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_full_unstemmed	A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_sort	review on anti-peptic ulcer activities of medicinal plants used in the formulation of enterica, dyspepsia and npk 500 capsules
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8d370449808048c5bb26bb95650846ef
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A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

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