Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
Lipopolysaccharides (LPS) are surface glycoconjugates embedded in the external leaflet of the outer membrane (OM) of the Gram-negative bacteria. They consist of three regions: lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-antigen. Lipid A is the glycolipid endotoxin domain t...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/8d3727b1305d417dab5999e8ee26b7aa |
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| Sumario: | Lipopolysaccharides (LPS) are surface glycoconjugates embedded in the external leaflet of the outer membrane (OM) of the Gram-negative bacteria. They consist of three regions: lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-antigen. Lipid A is the glycolipid endotoxin domain that anchors the LPS molecule to the OM, and therefore, its chemical structure is crucial in the maintenance of membrane integrity in the Gram-negative bacteria. In this paper, we reported the characterization of the lipid A and OS structures from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup>, which is a psychrotrophic Gram-negative bacterium isolated from the intestine of <i>Seriola quinqueradiata</i>. The immunomodulatory activity of both LPS and lipid A was also examined. |
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