Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity

Lipopolysaccharides (LPS) are surface glycoconjugates embedded in the external leaflet of the outer membrane (OM) of the Gram-negative bacteria. They consist of three regions: lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-antigen. Lipid A is the glycolipid endotoxin domain t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rossella Di Guida, Angela Casillo, Antonietta Stellavato, Celeste Di Meo, Soichiro Kawai, Jun Kawamoto, Takuya Ogawa, Tatsuo Kurihara, Chiara Schiraldi, Maria Michela Corsaro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cold-adapted endotoxin TLR-4 LPS structural characterization NMR Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8d3727b1305d417dab5999e8ee26b7aa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8d3727b1305d417dab5999e8ee26b7aa
record_format	dspace
spelling	oai:doaj.org-article:8d3727b1305d417dab5999e8ee26b7aa2021-11-25T18:13:04ZComplete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity10.3390/md191106461660-3397https://doaj.org/article/8d3727b1305d417dab5999e8ee26b7aa2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/646https://doaj.org/toc/1660-3397Lipopolysaccharides (LPS) are surface glycoconjugates embedded in the external leaflet of the outer membrane (OM) of the Gram-negative bacteria. They consist of three regions: lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-antigen. Lipid A is the glycolipid endotoxin domain that anchors the LPS molecule to the OM, and therefore, its chemical structure is crucial in the maintenance of membrane integrity in the Gram-negative bacteria. In this paper, we reported the characterization of the lipid A and OS structures from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup>, which is a psychrotrophic Gram-negative bacterium isolated from the intestine of <i>Seriola quinqueradiata</i>. The immunomodulatory activity of both LPS and lipid A was also examined.Rossella Di GuidaAngela CasilloAntonietta StellavatoCeleste Di MeoSoichiro KawaiJun KawamotoTakuya OgawaTatsuo KuriharaChiara SchiraldiMaria Michela CorsaroMDPI AGarticlecold-adaptedendotoxinTLR-4LPSstructural characterizationNMRBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 646, p 646 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cold-adapted endotoxin TLR-4 LPS structural characterization NMR Biology (General) QH301-705.5
spellingShingle	cold-adapted endotoxin TLR-4 LPS structural characterization NMR Biology (General) QH301-705.5 Rossella Di Guida Angela Casillo Antonietta Stellavato Celeste Di Meo Soichiro Kawai Jun Kawamoto Takuya Ogawa Tatsuo Kurihara Chiara Schiraldi Maria Michela Corsaro Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
description	Lipopolysaccharides (LPS) are surface glycoconjugates embedded in the external leaflet of the outer membrane (OM) of the Gram-negative bacteria. They consist of three regions: lipid A, core oligosaccharide (OS), and O-specific polysaccharide or O-antigen. Lipid A is the glycolipid endotoxin domain that anchors the LPS molecule to the OM, and therefore, its chemical structure is crucial in the maintenance of membrane integrity in the Gram-negative bacteria. In this paper, we reported the characterization of the lipid A and OS structures from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup>, which is a psychrotrophic Gram-negative bacterium isolated from the intestine of <i>Seriola quinqueradiata</i>. The immunomodulatory activity of both LPS and lipid A was also examined.
format	article
author	Rossella Di Guida Angela Casillo Antonietta Stellavato Celeste Di Meo Soichiro Kawai Jun Kawamoto Takuya Ogawa Tatsuo Kurihara Chiara Schiraldi Maria Michela Corsaro
author_facet	Rossella Di Guida Angela Casillo Antonietta Stellavato Celeste Di Meo Soichiro Kawai Jun Kawamoto Takuya Ogawa Tatsuo Kurihara Chiara Schiraldi Maria Michela Corsaro
author_sort	Rossella Di Guida
title	Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
title_short	Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
title_full	Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
title_fullStr	Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
title_full_unstemmed	Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity
title_sort	complete lipooligosaccharide structure from <i>pseudoalteromonas nigrifaciens</i> sq02-rif<sup>r</sup> and study of its immunomodulatory activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8d3727b1305d417dab5999e8ee26b7aa
work_keys_str_mv	AT rosselladiguida completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT angelacasillo completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT antoniettastellavato completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT celestedimeo completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT soichirokawai completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT junkawamoto completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT takuyaogawa completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT tatsuokurihara completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT chiaraschiraldi completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity AT mariamichelacorsaro completelipooligosaccharidestructurefromipseudoalteromonasnigrifaciensisq02rifsuprsupandstudyofitsimmunomodulatoryactivity
_version_	1718411450562641920

Complete Lipooligosaccharide Structure from <i>Pseudoalteromonas nigrifaciens</i> Sq02-Rif<sup>r</sup> and Study of Its Immunomodulatory Activity

Ejemplares similares