Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder

Objective: Depression among older adults is frequently an early symptom of cognitive decline, and is believed to be a risk factor for Alzheimer’s disease (AD). Hippocampal subfield volume loss is found in both mild cognitive impairment (MCI) and major depressive disorder (MDD). We aimed to investig...

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Autores principales:	Doonyaporn Wongsawaeng, Orasa Chawalparit, Siriwan Piyapittayanan, Tanyaluck Thientunyakit, Weerasak Muangpaisan, Kitikan Thana-udom, Panida Charnchaowanish, Chanon Ngamsombat
Formato:	article
Lenguaje:	EN
Publicado:	Mahidol University 2021
Materias:	Magnetic resonance hippocampal subfield volumetric analysis mild cognitive impairment (MCI) major depressive disorder (MDD) healthy older adults (HOA) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8d3c1e5c0db347c7afa55c0e39fb0e61
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spelling	oai:doaj.org-article:8d3c1e5c0db347c7afa55c0e39fb0e612021-12-01T10:07:40ZMagnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder10.33192/Smj.2021.1022228-8082https://doaj.org/article/8d3c1e5c0db347c7afa55c0e39fb0e612021-12-01T00:00:00Zhttps://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/254580https://doaj.org/toc/2228-8082 Objective: Depression among older adults is frequently an early symptom of cognitive decline, and is believed to be a risk factor for Alzheimer’s disease (AD). Hippocampal subfield volume loss is found in both mild cognitive impairment (MCI) and major depressive disorder (MDD). We aimed to investigate the potential of MR hippocampal subfield volumetry for discriminating among healthy older adults (HOA) and older adults with MCI or MDD. Materials and Methods: Seventy age-matched subjects (29 non-depressed MCI, 12 MDD, and 29 HOA) underwent 3-Tesla MR imaging (MRI) with high-resolution 3D-T1W-TFE whole brain. Hippocampal subfield volumetric measurements were performed using FreeSurfer software to distinguish among MCI, MDD, and HOA. Subgroup analysis with amyloid PET result was also performed. Results: Significantly smaller bilateral hippocampal tail volume was observed in MCI compared to HOA (p=0.004 and p=0.04 on the left and right side, respectively). The same comparative finding was observed at left HATA (hippocampus-amygdala-transition-area) of MCI (p=0.046). Other regions showed non-significantly smaller size in MCI than in HOA [left molecular layer HP (p=0.06), left whole hippocampus (p=0.06), and left CA1 (p=0.07)]. There was a non-significant trend toward smaller size in almost all 13 subfield hippocampal regions of MCI compared to MDD, even in subgroup analysis with amyloid PET result. Conclusion: MR hippocampal subfield volumetry may have value in routine clinical practice for screening individuals with MCI, and may be a valuable adjunct to amyloid PET study for very early-stage diagnosis of AD. Doonyaporn WongsawaengOrasa ChawalparitSiriwan PiyapittayananTanyaluck ThientunyakitWeerasak MuangpaisanKitikan Thana-udomPanida CharnchaowanishChanon NgamsombatMahidol UniversityarticleMagnetic resonance hippocampal subfield volumetric analysismild cognitive impairment (MCI)major depressive disorder (MDD)healthy older adults (HOA)Medicine (General)R5-920ENSiriraj Medical Journal, Vol 73, Iss 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Magnetic resonance hippocampal subfield volumetric analysis mild cognitive impairment (MCI) major depressive disorder (MDD) healthy older adults (HOA) Medicine (General) R5-920
spellingShingle	Magnetic resonance hippocampal subfield volumetric analysis mild cognitive impairment (MCI) major depressive disorder (MDD) healthy older adults (HOA) Medicine (General) R5-920 Doonyaporn Wongsawaeng Orasa Chawalparit Siriwan Piyapittayanan Tanyaluck Thientunyakit Weerasak Muangpaisan Kitikan Thana-udom Panida Charnchaowanish Chanon Ngamsombat Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder
description	Objective: Depression among older adults is frequently an early symptom of cognitive decline, and is believed to be a risk factor for Alzheimer’s disease (AD). Hippocampal subfield volume loss is found in both mild cognitive impairment (MCI) and major depressive disorder (MDD). We aimed to investigate the potential of MR hippocampal subfield volumetry for discriminating among healthy older adults (HOA) and older adults with MCI or MDD. Materials and Methods: Seventy age-matched subjects (29 non-depressed MCI, 12 MDD, and 29 HOA) underwent 3-Tesla MR imaging (MRI) with high-resolution 3D-T1W-TFE whole brain. Hippocampal subfield volumetric measurements were performed using FreeSurfer software to distinguish among MCI, MDD, and HOA. Subgroup analysis with amyloid PET result was also performed. Results: Significantly smaller bilateral hippocampal tail volume was observed in MCI compared to HOA (p=0.004 and p=0.04 on the left and right side, respectively). The same comparative finding was observed at left HATA (hippocampus-amygdala-transition-area) of MCI (p=0.046). Other regions showed non-significantly smaller size in MCI than in HOA [left molecular layer HP (p=0.06), left whole hippocampus (p=0.06), and left CA1 (p=0.07)]. There was a non-significant trend toward smaller size in almost all 13 subfield hippocampal regions of MCI compared to MDD, even in subgroup analysis with amyloid PET result. Conclusion: MR hippocampal subfield volumetry may have value in routine clinical practice for screening individuals with MCI, and may be a valuable adjunct to amyloid PET study for very early-stage diagnosis of AD.
format	article
author	Doonyaporn Wongsawaeng Orasa Chawalparit Siriwan Piyapittayanan Tanyaluck Thientunyakit Weerasak Muangpaisan Kitikan Thana-udom Panida Charnchaowanish Chanon Ngamsombat
author_facet	Doonyaporn Wongsawaeng Orasa Chawalparit Siriwan Piyapittayanan Tanyaluck Thientunyakit Weerasak Muangpaisan Kitikan Thana-udom Panida Charnchaowanish Chanon Ngamsombat
author_sort	Doonyaporn Wongsawaeng
title	Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder
title_short	Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder
title_full	Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder
title_fullStr	Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder
title_full_unstemmed	Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder
title_sort	magnetic resonance hippocampal subfield volumetric analysis for differentiating among healthy older adults and older adults with mild cognitive impairment or major depressive disorder
publisher	Mahidol University
publishDate	2021
url	https://doaj.org/article/8d3c1e5c0db347c7afa55c0e39fb0e61
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Magnetic Resonance Hippocampal Subfield Volumetric Analysis for Differentiating among Healthy Older Adults and Older Adults with Mild Cognitive Impairment or Major Depressive Disorder

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