Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis

Abstract Quantitative high resolution computed tomography (HRCT) may objectively assess systemic sclerosis (SSc)-interstitial lung disease (ILD) extent, using three basic densitometric measures: mean lung attenuation (MLA), skewness, and kurtosis. This prospective study aimed to develop a composite...

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Autores principales:	Marialuisa Bocchino, Dario Bruzzese, Michele D’Alto, Paola Argiento, Alessia Borgia, Annalisa Capaccio, Emanuele Romeo, Barbara Russo, Alessandro Sanduzzi, Tullio Valente, Nicola Sverzellati, Gaetano Rea, Serena Vettori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d3d06f2b8d64f75890092bcb7eead6a
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spelling	oai:doaj.org-article:8d3d06f2b8d64f75890092bcb7eead6a2021-12-02T15:08:31ZPerformance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis10.1038/s41598-019-45990-72045-2322https://doaj.org/article/8d3d06f2b8d64f75890092bcb7eead6a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45990-7https://doaj.org/toc/2045-2322Abstract Quantitative high resolution computed tomography (HRCT) may objectively assess systemic sclerosis (SSc)-interstitial lung disease (ILD) extent, using three basic densitometric measures: mean lung attenuation (MLA), skewness, and kurtosis. This prospective study aimed to develop a composite index - computerized integrated index (CII) – that accounted for MLA, skewness, and kurtosis by means of Principal Component Analysis over HRCTs of 83 consecutive SSc subjects, thus eliminating redundancies. Correlations among CII, cardiopulmonary function and immune-inflammatory biomarkers (e.g. sIL-2Rα and CCL18 serum levels) were explored. ILD was detected in 47% of patients at visual HRCT assessment. These patients had worse CII values than patients without ILD. The CII correlated with lung function at both baseline and follow-up, and with sIL-2Rα and CCL18 serum levels. The best discriminating CII value for ILD was 0.1966 (AUC = 0.77; sensitivity = 0.81 [95%CI:0.68–0.92]; specificity = 0.66 [95%CI:0.52–0.80]). Thirty-four percent of patients without visual trace of ILD had a CII lower than 0.1966, and 67% of them had a diffusing lung capacity for CO <80% of predicted. We showed that this new composite CT index for SSc-ILD assessment correlates with both lung function and immune-inflammatory parameters and could be sufficiently sensitive for capturing early lung density changes in visually ILD-free patients.Marialuisa BocchinoDario BruzzeseMichele D’AltoPaola ArgientoAlessia BorgiaAnnalisa CapaccioEmanuele RomeoBarbara RussoAlessandro SanduzziTullio ValenteNicola SverzellatiGaetano ReaSerena VettoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marialuisa Bocchino Dario Bruzzese Michele D’Alto Paola Argiento Alessia Borgia Annalisa Capaccio Emanuele Romeo Barbara Russo Alessandro Sanduzzi Tullio Valente Nicola Sverzellati Gaetano Rea Serena Vettori Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
description	Abstract Quantitative high resolution computed tomography (HRCT) may objectively assess systemic sclerosis (SSc)-interstitial lung disease (ILD) extent, using three basic densitometric measures: mean lung attenuation (MLA), skewness, and kurtosis. This prospective study aimed to develop a composite index - computerized integrated index (CII) – that accounted for MLA, skewness, and kurtosis by means of Principal Component Analysis over HRCTs of 83 consecutive SSc subjects, thus eliminating redundancies. Correlations among CII, cardiopulmonary function and immune-inflammatory biomarkers (e.g. sIL-2Rα and CCL18 serum levels) were explored. ILD was detected in 47% of patients at visual HRCT assessment. These patients had worse CII values than patients without ILD. The CII correlated with lung function at both baseline and follow-up, and with sIL-2Rα and CCL18 serum levels. The best discriminating CII value for ILD was 0.1966 (AUC = 0.77; sensitivity = 0.81 [95%CI:0.68–0.92]; specificity = 0.66 [95%CI:0.52–0.80]). Thirty-four percent of patients without visual trace of ILD had a CII lower than 0.1966, and 67% of them had a diffusing lung capacity for CO <80% of predicted. We showed that this new composite CT index for SSc-ILD assessment correlates with both lung function and immune-inflammatory parameters and could be sufficiently sensitive for capturing early lung density changes in visually ILD-free patients.
format	article
author	Marialuisa Bocchino Dario Bruzzese Michele D’Alto Paola Argiento Alessia Borgia Annalisa Capaccio Emanuele Romeo Barbara Russo Alessandro Sanduzzi Tullio Valente Nicola Sverzellati Gaetano Rea Serena Vettori
author_facet	Marialuisa Bocchino Dario Bruzzese Michele D’Alto Paola Argiento Alessia Borgia Annalisa Capaccio Emanuele Romeo Barbara Russo Alessandro Sanduzzi Tullio Valente Nicola Sverzellati Gaetano Rea Serena Vettori
author_sort	Marialuisa Bocchino
title	Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
title_short	Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
title_full	Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
title_fullStr	Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
title_full_unstemmed	Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
title_sort	performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8d3d06f2b8d64f75890092bcb7eead6a
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Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis

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