Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

Bone is innervated, and its turnover is affected by sympathetic nerve activity. Here, the authors show that prostaglandin E2, secreted by osteoblasts, activates the EP4 receptor on sensory nerves, inhibiting sympathetic nerve activity and modulating bone formation in mice.

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Autores principales:	Hao Chen, Bo Hu, Xiao Lv, Shouan Zhu, Gehua Zhen, Mei Wan, Amit Jain, Bo Gao, Yu Chai, Mi Yang, Xiao Wang, Ruoxian Deng, Lei Wang, Yong Cao, Shuangfei Ni, Shen Liu, Wen Yuan, Huajiang Chen, Xinzhong Dong, Yun Guan, Huilin Yang, Xu Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d431045fb1444baaa1a6a79863f3b83
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8d431045fb1444baaa1a6a79863f3b832021-12-02T16:57:30ZProstaglandin E2 mediates sensory nerve regulation of bone homeostasis10.1038/s41467-018-08097-72041-1723https://doaj.org/article/8d431045fb1444baaa1a6a79863f3b832019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08097-7https://doaj.org/toc/2041-1723Bone is innervated, and its turnover is affected by sympathetic nerve activity. Here, the authors show that prostaglandin E2, secreted by osteoblasts, activates the EP4 receptor on sensory nerves, inhibiting sympathetic nerve activity and modulating bone formation in mice.Hao ChenBo HuXiao LvShouan ZhuGehua ZhenMei WanAmit JainBo GaoYu ChaiMi YangXiao WangRuoxian DengLei WangYong CaoShuangfei NiShen LiuWen YuanHuajiang ChenXinzhong DongYun GuanHuilin YangXu CaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hao Chen Bo Hu Xiao Lv Shouan Zhu Gehua Zhen Mei Wan Amit Jain Bo Gao Yu Chai Mi Yang Xiao Wang Ruoxian Deng Lei Wang Yong Cao Shuangfei Ni Shen Liu Wen Yuan Huajiang Chen Xinzhong Dong Yun Guan Huilin Yang Xu Cao Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
description	Bone is innervated, and its turnover is affected by sympathetic nerve activity. Here, the authors show that prostaglandin E2, secreted by osteoblasts, activates the EP4 receptor on sensory nerves, inhibiting sympathetic nerve activity and modulating bone formation in mice.
format	article
author	Hao Chen Bo Hu Xiao Lv Shouan Zhu Gehua Zhen Mei Wan Amit Jain Bo Gao Yu Chai Mi Yang Xiao Wang Ruoxian Deng Lei Wang Yong Cao Shuangfei Ni Shen Liu Wen Yuan Huajiang Chen Xinzhong Dong Yun Guan Huilin Yang Xu Cao
author_facet	Hao Chen Bo Hu Xiao Lv Shouan Zhu Gehua Zhen Mei Wan Amit Jain Bo Gao Yu Chai Mi Yang Xiao Wang Ruoxian Deng Lei Wang Yong Cao Shuangfei Ni Shen Liu Wen Yuan Huajiang Chen Xinzhong Dong Yun Guan Huilin Yang Xu Cao
author_sort	Hao Chen
title	Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
title_short	Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
title_full	Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
title_fullStr	Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
title_full_unstemmed	Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
title_sort	prostaglandin e2 mediates sensory nerve regulation of bone homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8d431045fb1444baaa1a6a79863f3b83
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Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

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