Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.

<h4>Background</h4>A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we s...

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Autores principales:	Joost Smolders, Evelyn Peelen, Mariëlle Thewissen, Jan Willem Cohen Tervaert, Paul Menheere, Raymond Hupperts, Jan Damoiseaux
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d475bdfa289411aa74e8e1a4af52229
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spelling	oai:doaj.org-article:8d475bdfa289411aa74e8e1a4af522292021-11-18T07:01:49ZSafety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.1932-620310.1371/journal.pone.0015235https://doaj.org/article/8d475bdfa289411aa74e8e1a4af522292010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21179201/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D3 supplementation on safety and T cell related outcome measures.<h4>Methodology/principal findings</h4>Fifteen RRMS patients were supplemented with 20,000 IU/d vitamin D3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P<0.001). During the study, 1 patient experienced an exacerbation of MS and was censored from the T cell analysis. The proportions of (naïve and memory) CD4+ Tregs remained unaffected. Although Treg suppressive function improved in several subjects, this effect was not significant in the total cohort (P=0.143). An increased proportion of IL-10+ CD4+ T cells was found after supplementation (P=0.021). Additionally, a decrease of the ratio between IFN-γ+ and IL-4+ CD4+ T cells was observed (P=0.035).<h4>Conclusion/significance</h4>Twelve week supplementation of high dose vitamin D3 in RRMS patients was well tolerated and did not induce decompensation of calcium metabolism. The skewing towards an anti-inflammatory cytokine profile supports the evidence on vitamin D as an immune-modulator, and may be used as outcome measure for upcoming randomized placebo-controlled trials.<h4>Trial registration</h4>Clinicaltrials.gov NCT00940719.Joost SmoldersEvelyn PeelenMariëlle ThewissenJan Willem Cohen TervaertPaul MenheereRaymond HuppertsJan DamoiseauxPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e15235 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joost Smolders Evelyn Peelen Mariëlle Thewissen Jan Willem Cohen Tervaert Paul Menheere Raymond Hupperts Jan Damoiseaux Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
description	<h4>Background</h4>A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D3 supplementation on safety and T cell related outcome measures.<h4>Methodology/principal findings</h4>Fifteen RRMS patients were supplemented with 20,000 IU/d vitamin D3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P<0.001). During the study, 1 patient experienced an exacerbation of MS and was censored from the T cell analysis. The proportions of (naïve and memory) CD4+ Tregs remained unaffected. Although Treg suppressive function improved in several subjects, this effect was not significant in the total cohort (P=0.143). An increased proportion of IL-10+ CD4+ T cells was found after supplementation (P=0.021). Additionally, a decrease of the ratio between IFN-γ+ and IL-4+ CD4+ T cells was observed (P=0.035).<h4>Conclusion/significance</h4>Twelve week supplementation of high dose vitamin D3 in RRMS patients was well tolerated and did not induce decompensation of calcium metabolism. The skewing towards an anti-inflammatory cytokine profile supports the evidence on vitamin D as an immune-modulator, and may be used as outcome measure for upcoming randomized placebo-controlled trials.<h4>Trial registration</h4>Clinicaltrials.gov NCT00940719.
format	article
author	Joost Smolders Evelyn Peelen Mariëlle Thewissen Jan Willem Cohen Tervaert Paul Menheere Raymond Hupperts Jan Damoiseaux
author_facet	Joost Smolders Evelyn Peelen Mariëlle Thewissen Jan Willem Cohen Tervaert Paul Menheere Raymond Hupperts Jan Damoiseaux
author_sort	Joost Smolders
title	Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
title_short	Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
title_full	Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
title_fullStr	Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
title_full_unstemmed	Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
title_sort	safety and t cell modulating effects of high dose vitamin d3 supplementation in multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/8d475bdfa289411aa74e8e1a4af52229
work_keys_str_mv	AT joostsmolders safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis AT evelynpeelen safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis AT mariellethewissen safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis AT janwillemcohentervaert safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis AT paulmenheere safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis AT raymondhupperts safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis AT jandamoiseaux safetyandtcellmodulatingeffectsofhighdosevitamind3supplementationinmultiplesclerosis
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Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.

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