TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion protein that can limit collagen-induced arthr...

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Autores principales:	Rikio Yabe, Soo-Hyun Chung, Masanori A. Murayama, Sachiko Kubo, Kenji Shimizu, Yukiko Akahori, Takumi Maruhashi, Akimasa Seno, Tomonori Kaifu, Shinobu Saijo, Yoichiro Iwakura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d49d07e74404c8888ee493046f254e5
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spelling	oai:doaj.org-article:8d49d07e74404c8888ee493046f254e52021-12-02T11:56:18ZTARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens10.1038/s41467-020-20307-92041-1723https://doaj.org/article/8d49d07e74404c8888ee493046f254e52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20307-9https://doaj.org/toc/2041-1723TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion protein that can limit collagen-induced arthritis in mice.Rikio YabeSoo-Hyun ChungMasanori A. MurayamaSachiko KuboKenji ShimizuYukiko AkahoriTakumi MaruhashiAkimasa SenoTomonori KaifuShinobu SaijoYoichiro IwakuraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rikio Yabe Soo-Hyun Chung Masanori A. Murayama Sachiko Kubo Kenji Shimizu Yukiko Akahori Takumi Maruhashi Akimasa Seno Tomonori Kaifu Shinobu Saijo Yoichiro Iwakura TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
description	TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion protein that can limit collagen-induced arthritis in mice.
format	article
author	Rikio Yabe Soo-Hyun Chung Masanori A. Murayama Sachiko Kubo Kenji Shimizu Yukiko Akahori Takumi Maruhashi Akimasa Seno Tomonori Kaifu Shinobu Saijo Yoichiro Iwakura
author_facet	Rikio Yabe Soo-Hyun Chung Masanori A. Murayama Sachiko Kubo Kenji Shimizu Yukiko Akahori Takumi Maruhashi Akimasa Seno Tomonori Kaifu Shinobu Saijo Yoichiro Iwakura
author_sort	Rikio Yabe
title	TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
title_short	TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
title_full	TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
title_fullStr	TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
title_full_unstemmed	TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
title_sort	tarm1 contributes to development of arthritis by activating dendritic cells through recognition of collagens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d49d07e74404c8888ee493046f254e5
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TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

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