Swapping of transmembrane domains in the epithelial calcium channel TRPV6

Abstract Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain...

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Autores principales:	Appu K. Singh, Kei Saotome, Alexander I. Sobolevsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d4ad1fda5c14cfdb1eca03562e357f2
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spelling	oai:doaj.org-article:8d4ad1fda5c14cfdb1eca03562e357f22021-12-02T15:05:07ZSwapping of transmembrane domains in the epithelial calcium channel TRPV610.1038/s41598-017-10993-92045-2322https://doaj.org/article/8d4ad1fda5c14cfdb1eca03562e357f22017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10993-9https://doaj.org/toc/2045-2322Abstract Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.Appu K. SinghKei SaotomeAlexander I. SobolevskyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Appu K. Singh Kei Saotome Alexander I. Sobolevsky Swapping of transmembrane domains in the epithelial calcium channel TRPV6
description	Abstract Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.
format	article
author	Appu K. Singh Kei Saotome Alexander I. Sobolevsky
author_facet	Appu K. Singh Kei Saotome Alexander I. Sobolevsky
author_sort	Appu K. Singh
title	Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_short	Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_full	Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_fullStr	Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_full_unstemmed	Swapping of transmembrane domains in the epithelial calcium channel TRPV6
title_sort	swapping of transmembrane domains in the epithelial calcium channel trpv6
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8d4ad1fda5c14cfdb1eca03562e357f2
work_keys_str_mv	AT appuksingh swappingoftransmembranedomainsintheepithelialcalciumchanneltrpv6 AT keisaotome swappingoftransmembranedomainsintheepithelialcalciumchanneltrpv6 AT alexanderisobolevsky swappingoftransmembranedomainsintheepithelialcalciumchanneltrpv6
_version_	1718388968824766464

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

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