A synthetic ion channel with anisotropic ligand response

Transmembrane proteins are important for cellular functions and synthetic analogues are of interest. Here the authors report on the design and testing of a synthetic multipass transmembrane channel which shows anisotropic responses to agonistic and antagonistic ligands.

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Bibliographic Details
Main Authors:	Takahiro Muraoka, Daiki Noguchi, Rinshi S. Kasai, Kohei Sato, Ryo Sasaki, Kazuhito V. Tabata, Toru Ekimoto, Mitsunori Ikeguchi, Kiyoto Kamagata, Norihisa Hoshino, Hiroyuki Noji, Tomoyuki Akutagawa, Kazuaki Ichimura, Kazushi Kinbara
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/8d4b05d38a764d63897b3b2f6cc88bf5
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id	oai:doaj.org-article:8d4b05d38a764d63897b3b2f6cc88bf5
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spelling	oai:doaj.org-article:8d4b05d38a764d63897b3b2f6cc88bf52021-12-02T17:47:59ZA synthetic ion channel with anisotropic ligand response10.1038/s41467-020-16770-z2041-1723https://doaj.org/article/8d4b05d38a764d63897b3b2f6cc88bf52020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16770-zhttps://doaj.org/toc/2041-1723Transmembrane proteins are important for cellular functions and synthetic analogues are of interest. Here the authors report on the design and testing of a synthetic multipass transmembrane channel which shows anisotropic responses to agonistic and antagonistic ligands.Takahiro MuraokaDaiki NoguchiRinshi S. KasaiKohei SatoRyo SasakiKazuhito V. TabataToru EkimotoMitsunori IkeguchiKiyoto KamagataNorihisa HoshinoHiroyuki NojiTomoyuki AkutagawaKazuaki IchimuraKazushi KinbaraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takahiro Muraoka Daiki Noguchi Rinshi S. Kasai Kohei Sato Ryo Sasaki Kazuhito V. Tabata Toru Ekimoto Mitsunori Ikeguchi Kiyoto Kamagata Norihisa Hoshino Hiroyuki Noji Tomoyuki Akutagawa Kazuaki Ichimura Kazushi Kinbara A synthetic ion channel with anisotropic ligand response
description	Transmembrane proteins are important for cellular functions and synthetic analogues are of interest. Here the authors report on the design and testing of a synthetic multipass transmembrane channel which shows anisotropic responses to agonistic and antagonistic ligands.
format	article
author	Takahiro Muraoka Daiki Noguchi Rinshi S. Kasai Kohei Sato Ryo Sasaki Kazuhito V. Tabata Toru Ekimoto Mitsunori Ikeguchi Kiyoto Kamagata Norihisa Hoshino Hiroyuki Noji Tomoyuki Akutagawa Kazuaki Ichimura Kazushi Kinbara
author_facet	Takahiro Muraoka Daiki Noguchi Rinshi S. Kasai Kohei Sato Ryo Sasaki Kazuhito V. Tabata Toru Ekimoto Mitsunori Ikeguchi Kiyoto Kamagata Norihisa Hoshino Hiroyuki Noji Tomoyuki Akutagawa Kazuaki Ichimura Kazushi Kinbara
author_sort	Takahiro Muraoka
title	A synthetic ion channel with anisotropic ligand response
title_short	A synthetic ion channel with anisotropic ligand response
title_full	A synthetic ion channel with anisotropic ligand response
title_fullStr	A synthetic ion channel with anisotropic ligand response
title_full_unstemmed	A synthetic ion channel with anisotropic ligand response
title_sort	synthetic ion channel with anisotropic ligand response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d4b05d38a764d63897b3b2f6cc88bf5
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A synthetic ion channel with anisotropic ligand response

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