Effects of carbon nanofiber on physiology of Drosophila

Shin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min11Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea*These authors contributed equa...

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Autores principales:	Lee SH, Lee HY, Lee EJ, Khang D, Min KJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8d4cd29bdb214348bcc5357a15817fa9
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spelling	oai:doaj.org-article:8d4cd29bdb214348bcc5357a15817fa92021-12-02T00:20:48ZEffects of carbon nanofiber on physiology of Drosophila1178-2013https://doaj.org/article/8d4cd29bdb214348bcc5357a15817fa92015-05-01T00:00:00Zhttp://www.dovepress.com/effects-of-carbon-nanofiber-on-physiology-of-drosophila-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min11Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea*These authors contributed equally to this workAbstract: As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 µg/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 µg/mL) reduced larval viability based on the pupa:egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 µg/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 µg/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.Keywords: toxicity, Drosophila melanogaster, lifespan, reactive oxygen speciesLee SHLee HYLee EJKhang DMin KJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3687-3697 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lee SH Lee HY Lee EJ Khang D Min KJ Effects of carbon nanofiber on physiology of Drosophila
description	Shin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min11Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea*These authors contributed equally to this workAbstract: As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 µg/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 µg/mL) reduced larval viability based on the pupa:egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 µg/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 µg/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.Keywords: toxicity, Drosophila melanogaster, lifespan, reactive oxygen species
format	article
author	Lee SH Lee HY Lee EJ Khang D Min KJ
author_facet	Lee SH Lee HY Lee EJ Khang D Min KJ
author_sort	Lee SH
title	Effects of carbon nanofiber on physiology of Drosophila
title_short	Effects of carbon nanofiber on physiology of Drosophila
title_full	Effects of carbon nanofiber on physiology of Drosophila
title_fullStr	Effects of carbon nanofiber on physiology of Drosophila
title_full_unstemmed	Effects of carbon nanofiber on physiology of Drosophila
title_sort	effects of carbon nanofiber on physiology of drosophila
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8d4cd29bdb214348bcc5357a15817fa9
work_keys_str_mv	AT leesh effectsofcarbonnanofiberonphysiologyofdrosophila AT leehy effectsofcarbonnanofiberonphysiologyofdrosophila AT leeej effectsofcarbonnanofiberonphysiologyofdrosophila AT khangd effectsofcarbonnanofiberonphysiologyofdrosophila AT minkj effectsofcarbonnanofiberonphysiologyofdrosophila
_version_	1718403814904561664

Effects of carbon nanofiber on physiology of Drosophila

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