Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving the way for the development of pre-exposure proph...

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Autores principales:	Nina Derby, Manjari Lal, Meropi Aravantinou, Larisa Kizima, Patrick Barnable, Aixa Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R O’Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José A. Fernández-Romero, Thomas M. Zydowsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d4f42eeb266482fa22316c03e392e44
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spelling	oai:doaj.org-article:8d4f42eeb266482fa22316c03e392e442021-12-02T16:49:17ZGriffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo10.1038/s41467-018-06349-02041-1723https://doaj.org/article/8d4f42eeb266482fa22316c03e392e442018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06349-0https://doaj.org/toc/2041-1723Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving the way for the development of pre-exposure prophylaxis on-demand products.Nina DerbyManjari LalMeropi AravantinouLarisa KizimaPatrick BarnableAixa RodriguezManshun LaiAsa WesenbergShweta UgaonkarKeith LevendoskyOlga MizeninaKyle KleinbeckJeffrey D. LifsonM. Melissa PeetZachary LloydMichael BensonWalid HeneineBarry R O’KeefeMelissa RobbianiElena MartinelliBrooke GraspergeJames BlanchardAgegnehu GettieNatalia TeleshovaJosé A. Fernández-RomeroThomas M. ZydowskyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nina Derby Manjari Lal Meropi Aravantinou Larisa Kizima Patrick Barnable Aixa Rodriguez Manshun Lai Asa Wesenberg Shweta Ugaonkar Keith Levendosky Olga Mizenina Kyle Kleinbeck Jeffrey D. Lifson M. Melissa Peet Zachary Lloyd Michael Benson Walid Heneine Barry R O’Keefe Melissa Robbiani Elena Martinelli Brooke Grasperge James Blanchard Agegnehu Gettie Natalia Teleshova José A. Fernández-Romero Thomas M. Zydowsky Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
description	Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving the way for the development of pre-exposure prophylaxis on-demand products.
format	article
author	Nina Derby Manjari Lal Meropi Aravantinou Larisa Kizima Patrick Barnable Aixa Rodriguez Manshun Lai Asa Wesenberg Shweta Ugaonkar Keith Levendosky Olga Mizenina Kyle Kleinbeck Jeffrey D. Lifson M. Melissa Peet Zachary Lloyd Michael Benson Walid Heneine Barry R O’Keefe Melissa Robbiani Elena Martinelli Brooke Grasperge James Blanchard Agegnehu Gettie Natalia Teleshova José A. Fernández-Romero Thomas M. Zydowsky
author_facet	Nina Derby Manjari Lal Meropi Aravantinou Larisa Kizima Patrick Barnable Aixa Rodriguez Manshun Lai Asa Wesenberg Shweta Ugaonkar Keith Levendosky Olga Mizenina Kyle Kleinbeck Jeffrey D. Lifson M. Melissa Peet Zachary Lloyd Michael Benson Walid Heneine Barry R O’Keefe Melissa Robbiani Elena Martinelli Brooke Grasperge James Blanchard Agegnehu Gettie Natalia Teleshova José A. Fernández-Romero Thomas M. Zydowsky
author_sort	Nina Derby
title	Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
title_short	Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
title_full	Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
title_fullStr	Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
title_full_unstemmed	Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
title_sort	griffithsin carrageenan fast dissolving inserts prevent shiv hsv-2 and hpv infections in vivo
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8d4f42eeb266482fa22316c03e392e44
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Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

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