State of gut microbiota and dietary preferences in obese adolescents

Aim. To study the features of food preferences and the state of gut microbiota in obese adolescents. Materials and Methods. The study involved 71 obese adolescents (49.3% - girls, 50.7% -boys) aged 12-17 years, who were treated at the SI "Institute for Children and Adolescent Health Care at...

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Autores principales:	L.K. Parkhomenko, L.A. Strashok, M.A. Khomenko, T.P. Osolodchenko
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2020
Materias:	obesity, adolescents, nafld, microbiota, eating habits Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8d4f93bb69c741ad941cb5715cd14a66
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spelling	oai:doaj.org-article:8d4f93bb69c741ad941cb5715cd14a662021-11-10T19:49:51ZState of gut microbiota and dietary preferences in obese adolescents1029-42442415-330310.25040/aml2020.01.040https://doaj.org/article/8d4f93bb69c741ad941cb5715cd14a662020-02-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/39https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To study the features of food preferences and the state of gut microbiota in obese adolescents. Materials and Methods. The study involved 71 obese adolescents (49.3% - girls, 50.7% -boys) aged 12-17 years, who were treated at the SI "Institute for Children and Adolescent Health Care at the National Academy of Medical Sciences of Ukraine". All the examined subjects underwent clinical, laboratory and instrumental examination; 55 obese adolescents underwent microbiological examination of feces. The control group included 18 healthy adolescents. Results and Discussion. The study revealed that most frequently the patients complained of increased appetite - 71.8%, dyspeptic symptoms - 54.9%, and abdominal pain - 52.1%. There was a significantly higher frequency of irregular eating schedule (74.6% vs 33.3%), late dinner (69.0% vs 27.8%), fast food consumption (33.8% vs 11.1%), and a significantly lower content of vegetables and fruit in the diet (54.9% vs 83.4%) in patients compared to healthy individuals. Insulin resistance in 63.4% and pathological changes in lipid levels in 66.2% of obese adolescents were noted. According to the results of ultrasound examination, an enlarged liver was determined in 95.8% of obese adolescents; an increase in echogenicity and decreased sound conduction of the liver parenchyma were noted in 74.6% of obese subjects. Upon microbiological examination of the faeces, it was found that 78.2% of obese adolescents presented with dysbiotic changes. Glucose levels and a homeostatic model assessment were significantly higher in obese adolescents with dysbiosis. Conclusions. Violations of eating regime and state of the gut microbiota were found in ¾ of obese adolescents.More than a half of obese adolescents presented with insulin resistance and disturbed lipid metabolism; moreover, in the presence of dysbiotic changes, disturbances of carbohydrate metabolism were more significant. There were signs of liver steatosis in the majority of obese adolescents.L.K. ParkhomenkoL.A. StrashokM.A. KhomenkoT.P. OsolodchenkoDanylo Halytsky Lviv National Medical Universityarticleobesity, adolescents, nafld, microbiota, eating habitsMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 26, Iss 1, Pp 40-46 (2020)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	obesity, adolescents, nafld, microbiota, eating habits Medicine (General) R5-920
spellingShingle	obesity, adolescents, nafld, microbiota, eating habits Medicine (General) R5-920 L.K. Parkhomenko L.A. Strashok M.A. Khomenko T.P. Osolodchenko State of gut microbiota and dietary preferences in obese adolescents
description	Aim. To study the features of food preferences and the state of gut microbiota in obese adolescents. Materials and Methods. The study involved 71 obese adolescents (49.3% - girls, 50.7% -boys) aged 12-17 years, who were treated at the SI "Institute for Children and Adolescent Health Care at the National Academy of Medical Sciences of Ukraine". All the examined subjects underwent clinical, laboratory and instrumental examination; 55 obese adolescents underwent microbiological examination of feces. The control group included 18 healthy adolescents. Results and Discussion. The study revealed that most frequently the patients complained of increased appetite - 71.8%, dyspeptic symptoms - 54.9%, and abdominal pain - 52.1%. There was a significantly higher frequency of irregular eating schedule (74.6% vs 33.3%), late dinner (69.0% vs 27.8%), fast food consumption (33.8% vs 11.1%), and a significantly lower content of vegetables and fruit in the diet (54.9% vs 83.4%) in patients compared to healthy individuals. Insulin resistance in 63.4% and pathological changes in lipid levels in 66.2% of obese adolescents were noted. According to the results of ultrasound examination, an enlarged liver was determined in 95.8% of obese adolescents; an increase in echogenicity and decreased sound conduction of the liver parenchyma were noted in 74.6% of obese subjects. Upon microbiological examination of the faeces, it was found that 78.2% of obese adolescents presented with dysbiotic changes. Glucose levels and a homeostatic model assessment were significantly higher in obese adolescents with dysbiosis. Conclusions. Violations of eating regime and state of the gut microbiota were found in ¾ of obese adolescents.More than a half of obese adolescents presented with insulin resistance and disturbed lipid metabolism; moreover, in the presence of dysbiotic changes, disturbances of carbohydrate metabolism were more significant. There were signs of liver steatosis in the majority of obese adolescents.
format	article
author	L.K. Parkhomenko L.A. Strashok M.A. Khomenko T.P. Osolodchenko
author_facet	L.K. Parkhomenko L.A. Strashok M.A. Khomenko T.P. Osolodchenko
author_sort	L.K. Parkhomenko
title	State of gut microbiota and dietary preferences in obese adolescents
title_short	State of gut microbiota and dietary preferences in obese adolescents
title_full	State of gut microbiota and dietary preferences in obese adolescents
title_fullStr	State of gut microbiota and dietary preferences in obese adolescents
title_full_unstemmed	State of gut microbiota and dietary preferences in obese adolescents
title_sort	state of gut microbiota and dietary preferences in obese adolescents
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2020
url	https://doaj.org/article/8d4f93bb69c741ad941cb5715cd14a66
work_keys_str_mv	AT lkparkhomenko stateofgutmicrobiotaanddietarypreferencesinobeseadolescents AT lastrashok stateofgutmicrobiotaanddietarypreferencesinobeseadolescents AT makhomenko stateofgutmicrobiotaanddietarypreferencesinobeseadolescents AT tposolodchenko stateofgutmicrobiotaanddietarypreferencesinobeseadolescents
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State of gut microbiota and dietary preferences in obese adolescents

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