Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.

Critical period plasticity at adult-born neuron synapses is widely believed to contribute to the learning and memory functions of the hippocampus. Experience regulates circuit integration and for a transient interval, until cells are ~6 weeks old, new neurons display enhanced long-term potentiation...

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Autores principales:	Nicholas P Vyleta, Jason S Snyder
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d50f6d49298495dbb967faf556aa793
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spelling	oai:doaj.org-article:8d50f6d49298495dbb967faf556aa7932021-12-02T20:10:22ZProlonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.1932-620310.1371/journal.pone.0253642https://doaj.org/article/8d50f6d49298495dbb967faf556aa7932021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253642https://doaj.org/toc/1932-6203Critical period plasticity at adult-born neuron synapses is widely believed to contribute to the learning and memory functions of the hippocampus. Experience regulates circuit integration and for a transient interval, until cells are ~6 weeks old, new neurons display enhanced long-term potentiation (LTP) at afferent and efferent synapses. Since neurogenesis declines substantially with age, this raises questions about the extent of lasting plasticity offered by adult-born neurons. Notably, however, the hippocampus receives sensory information from two major cortical pathways. Broadly speaking, the medial entorhinal cortex conveys spatial information to the hippocampus via the medial perforant path (MPP), and the lateral entorhinal cortex, via the lateral perforant path (LPP), codes for the cues and items that make experiences unique. While enhanced critical period plasticity at MPP synapses is relatively well characterized, no studies have examined long-term plasticity at LPP synapses onto adult-born neurons, even though the lateral entorhinal cortex is uniquely vulnerable to aging and Alzheimer's pathology. We therefore investigated LTP at LPP inputs both within (4-6 weeks) and beyond (8+ weeks) the traditional critical period. At immature stages, adult-born neurons did not undergo significant LTP at LPP synapses, and often displayed long-term depression after theta burst stimulation. However, over the course of 3-4 months, adult-born neurons displayed increasingly greater amounts of LTP. Analyses of short-term plasticity point towards a presynaptic mechanism, where transmitter release probability declines as cells mature, providing a greater dynamic range for strengthening synapses. Collectively, our findings identify a novel form of new neuron plasticity that develops over an extended interval, and may therefore be relevant for maintaining cognitive function in aging.Nicholas P VyletaJason S SnyderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253642 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicholas P Vyleta Jason S Snyder Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
description	Critical period plasticity at adult-born neuron synapses is widely believed to contribute to the learning and memory functions of the hippocampus. Experience regulates circuit integration and for a transient interval, until cells are ~6 weeks old, new neurons display enhanced long-term potentiation (LTP) at afferent and efferent synapses. Since neurogenesis declines substantially with age, this raises questions about the extent of lasting plasticity offered by adult-born neurons. Notably, however, the hippocampus receives sensory information from two major cortical pathways. Broadly speaking, the medial entorhinal cortex conveys spatial information to the hippocampus via the medial perforant path (MPP), and the lateral entorhinal cortex, via the lateral perforant path (LPP), codes for the cues and items that make experiences unique. While enhanced critical period plasticity at MPP synapses is relatively well characterized, no studies have examined long-term plasticity at LPP synapses onto adult-born neurons, even though the lateral entorhinal cortex is uniquely vulnerable to aging and Alzheimer's pathology. We therefore investigated LTP at LPP inputs both within (4-6 weeks) and beyond (8+ weeks) the traditional critical period. At immature stages, adult-born neurons did not undergo significant LTP at LPP synapses, and often displayed long-term depression after theta burst stimulation. However, over the course of 3-4 months, adult-born neurons displayed increasingly greater amounts of LTP. Analyses of short-term plasticity point towards a presynaptic mechanism, where transmitter release probability declines as cells mature, providing a greater dynamic range for strengthening synapses. Collectively, our findings identify a novel form of new neuron plasticity that develops over an extended interval, and may therefore be relevant for maintaining cognitive function in aging.
format	article
author	Nicholas P Vyleta Jason S Snyder
author_facet	Nicholas P Vyleta Jason S Snyder
author_sort	Nicholas P Vyleta
title	Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
title_short	Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
title_full	Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
title_fullStr	Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
title_full_unstemmed	Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
title_sort	prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8d50f6d49298495dbb967faf556aa793
work_keys_str_mv	AT nicholaspvyleta prolongeddevelopmentoflongtermpotentiationatlateralentorhinalcortexsynapsesontoadultbornneurons AT jasonssnyder prolongeddevelopmentoflongtermpotentiationatlateralentorhinalcortexsynapsesontoadultbornneurons
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Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.

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