An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease

Tafere Mulaw Belete Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tafere Mulaw Belete Tel +251 918045943Email mutafere@yahoo.comAbstract: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has a great potential...

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Autor principal:	Mulaw Belete T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	corona virus sars-cov-2 sars-cov covid-19 chloroquine Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8d554f858af04c90b29dc8788b26d7cb
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spelling	oai:doaj.org-article:8d554f858af04c90b29dc8788b26d7cb2021-12-02T11:45:06ZAn Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease1179-1438https://doaj.org/article/8d554f858af04c90b29dc8788b26d7cb2020-12-01T00:00:00Zhttps://www.dovepress.com/an-up-to-date-overview-of-therapeutic-agents-for-the-treatment-of-covi-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Tafere Mulaw Belete Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tafere Mulaw Belete Tel +251 918045943Email mutafere@yahoo.comAbstract: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has a great potential to overwhelm the world healthcare systems that may lead to high morbidity and mortality. It also affects world economic development in the future. Currently, no proven effective drugs or vaccines are available for the management of COVID-19 disease. The pace of normal drug development progression is unacceptable in the context of the current pandemic. Therefore, repurposing the existing drugs that were used for the treatment of malaria, Ebola, and influenza helps rapid drug development for COVID-19. Currently, several repurposing candidate drugs are in a clinical trial including, chloroquine monoclonal antibodies, convalescent plasma, interferon, and antiviral therapies. Antiviral drugs like arbidol, remdesiv and favirnavir are the most promising due to the similarities of the viruses regarding viral entry, fusion, uncoating, and replication. This review article provides an overview of the potential therapeutic agent, which displayed better clinical treatment outcomes. Moreover, with further understanding of the SARS-CoV-2 virus, new drugs targeting specific SARS-CoV-2 viral components arise, and investigations on these novels anti-SARSCoV- 2 agents are also reviewed.Keywords: corona virus, SARS-CoV-2, SARS-CoV, COVID-19, chloroquineMulaw Belete TDove Medical Pressarticlecorona virussars-cov-2sars-covcovid-19chloroquineTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 12, Pp 203-212 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	corona virus sars-cov-2 sars-cov covid-19 chloroquine Therapeutics. Pharmacology RM1-950
spellingShingle	corona virus sars-cov-2 sars-cov covid-19 chloroquine Therapeutics. Pharmacology RM1-950 Mulaw Belete T An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
description	Tafere Mulaw Belete Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tafere Mulaw Belete Tel +251 918045943Email mutafere@yahoo.comAbstract: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has a great potential to overwhelm the world healthcare systems that may lead to high morbidity and mortality. It also affects world economic development in the future. Currently, no proven effective drugs or vaccines are available for the management of COVID-19 disease. The pace of normal drug development progression is unacceptable in the context of the current pandemic. Therefore, repurposing the existing drugs that were used for the treatment of malaria, Ebola, and influenza helps rapid drug development for COVID-19. Currently, several repurposing candidate drugs are in a clinical trial including, chloroquine monoclonal antibodies, convalescent plasma, interferon, and antiviral therapies. Antiviral drugs like arbidol, remdesiv and favirnavir are the most promising due to the similarities of the viruses regarding viral entry, fusion, uncoating, and replication. This review article provides an overview of the potential therapeutic agent, which displayed better clinical treatment outcomes. Moreover, with further understanding of the SARS-CoV-2 virus, new drugs targeting specific SARS-CoV-2 viral components arise, and investigations on these novels anti-SARSCoV- 2 agents are also reviewed.Keywords: corona virus, SARS-CoV-2, SARS-CoV, COVID-19, chloroquine
format	article
author	Mulaw Belete T
author_facet	Mulaw Belete T
author_sort	Mulaw Belete T
title	An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
title_short	An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
title_full	An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
title_fullStr	An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
title_full_unstemmed	An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease
title_sort	up-to-date overview of therapeutic agents for the treatment of covid-19 disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8d554f858af04c90b29dc8788b26d7cb
work_keys_str_mv	AT mulawbeletet anuptodateoverviewoftherapeuticagentsforthetreatmentofcovid19disease AT mulawbeletet uptodateoverviewoftherapeuticagentsforthetreatmentofcovid19disease
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An Up-to-Date Overview of Therapeutic Agents for the Treatment of COVID-19 Disease

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