Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials

RangRang Fan,1 XiaoHui Deng,2 LiangXue Zhou,1 Xiang Gao,1 Min Fan,1 YueLong Wang,1 Gang Guo11State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 2Department of Human Anatomy, Xinxiang Medical...

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Autores principales:	Fan RR, Deng XH, Zhou LX, Gao X, Fan M, Wang YL, Guo G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8d5738d971ec4a91ab6ac9848f2931bb
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spelling	oai:doaj.org-article:8d5738d971ec4a91ab6ac9848f2931bb2021-12-02T01:32:21ZInjectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials1178-2013https://doaj.org/article/8d5738d971ec4a91ab6ac9848f2931bb2014-01-01T00:00:00Zhttp://www.dovepress.com/injectable-thermosensitive-hydrogel-composite-with-surface-functionali-a15583https://doaj.org/toc/1178-2013 RangRang Fan,1 XiaoHui Deng,2 LiangXue Zhou,1 Xiang Gao,1 Min Fan,1 YueLong Wang,1 Gang Guo11State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 2Department of Human Anatomy, Xinxiang Medical University, Xinxiang, People's Republic of ChinaAbstract: In this study, L-lactide was used to modify the tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP) surface which can form functionalized poly(l-lactic acid) (PLLA)-grafted β-TCP (g-β-TCP) and PLLA-grafted TTCP (g-TTCP) particles. The g-β-TCP and g-TTCP obtained were incorporated into a PEG-PCL-PEG (PECE) matrix to prepare injectable thermosensitive hydrogel composites. The morphology of the hydrogel composites showed that the g-β-TCP and g-TTCP particles dispersed homogeneously into the polymer matrix, and each hydrogel composite had a three-dimensional network structure. Rheologic analysis showed that the composite had good thermosensitivity. Changes in calcium concentration and pH in simulated body fluid solutions confirmed the feasibility of surface-functionalized calcium phosphate for controlled release of calcium. All the results indicate that g-β-TCP/PECE and g-TTCP/PECE hydrogels might be a promising protocol for tissue engineering.Keywords: injectable, thermosensitivity, surface functionalization, calcium phosphate, biocompatibilityFan RRDeng XHZhou LXGao XFan MWang YLGuo GDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 615-626 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Fan RR Deng XH Zhou LX Gao X Fan M Wang YL Guo G Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
description	RangRang Fan,1 XiaoHui Deng,2 LiangXue Zhou,1 Xiang Gao,1 Min Fan,1 YueLong Wang,1 Gang Guo11State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, 2Department of Human Anatomy, Xinxiang Medical University, Xinxiang, People's Republic of ChinaAbstract: In this study, L-lactide was used to modify the tricalcium phosphate (β-TCP) and tetracalcium phosphate (TTCP) surface which can form functionalized poly(l-lactic acid) (PLLA)-grafted β-TCP (g-β-TCP) and PLLA-grafted TTCP (g-TTCP) particles. The g-β-TCP and g-TTCP obtained were incorporated into a PEG-PCL-PEG (PECE) matrix to prepare injectable thermosensitive hydrogel composites. The morphology of the hydrogel composites showed that the g-β-TCP and g-TTCP particles dispersed homogeneously into the polymer matrix, and each hydrogel composite had a three-dimensional network structure. Rheologic analysis showed that the composite had good thermosensitivity. Changes in calcium concentration and pH in simulated body fluid solutions confirmed the feasibility of surface-functionalized calcium phosphate for controlled release of calcium. All the results indicate that g-β-TCP/PECE and g-TTCP/PECE hydrogels might be a promising protocol for tissue engineering.Keywords: injectable, thermosensitivity, surface functionalization, calcium phosphate, biocompatibility
format	article
author	Fan RR Deng XH Zhou LX Gao X Fan M Wang YL Guo G
author_facet	Fan RR Deng XH Zhou LX Gao X Fan M Wang YL Guo G
author_sort	Fan RR
title	Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
title_short	Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
title_full	Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
title_fullStr	Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
title_full_unstemmed	Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
title_sort	injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8d5738d971ec4a91ab6ac9848f2931bb
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Injectable thermosensitive hydrogel composite with surface-functionalized calcium phosphate as raw materials

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