The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

The poly-SUMO2/3 protease SENP6 enables assembly of the constitutive centromere-associated network by group deSUMOylation

While the biological roles of ubiquitin chains are well studied, little is known about the functions of SUMO polymers. Here, the authors identify poly-SUMOylation substrates and provide evidence that SUMO polymers regulate the accumulation of CCAN subunits at chromatin and centromeres.

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Detalles Bibliográficos
Autores principales: Frauke Liebelt, Nicolette S. Jansen, Sumit Kumar, Ekaterina Gracheva, Laura A. Claessens, Matty Verlaan-de Vries, Edwin Willemstein, Alfred C. O. Vertegaal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/8d573a3ede6f4566ad9972c15b4cb8c0
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