Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.

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Autores principales:	Olesia Ignatenko, Dmitri Chilov, Ilse Paetau, Elena de Miguel, Christopher B. Jackson, Gabrielle Capin, Anders Paetau, Mugen Terzioglu, Liliya Euro, Anu Suomalainen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d59af2ffbf5490da6e60f5f6221a5f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8d59af2ffbf5490da6e60f5f6221a5f02021-12-02T16:50:06ZLoss of mtDNA activates astrocytes and leads to spongiotic encephalopathy10.1038/s41467-017-01859-92041-1723https://doaj.org/article/8d59af2ffbf5490da6e60f5f6221a5f02018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01859-9https://doaj.org/toc/2041-1723Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.Olesia IgnatenkoDmitri ChilovIlse PaetauElena de MiguelChristopher B. JacksonGabrielle CapinAnders PaetauMugen TerziogluLiliya EuroAnu SuomalainenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olesia Ignatenko Dmitri Chilov Ilse Paetau Elena de Miguel Christopher B. Jackson Gabrielle Capin Anders Paetau Mugen Terzioglu Liliya Euro Anu Suomalainen Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
description	Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.
format	article
author	Olesia Ignatenko Dmitri Chilov Ilse Paetau Elena de Miguel Christopher B. Jackson Gabrielle Capin Anders Paetau Mugen Terzioglu Liliya Euro Anu Suomalainen
author_facet	Olesia Ignatenko Dmitri Chilov Ilse Paetau Elena de Miguel Christopher B. Jackson Gabrielle Capin Anders Paetau Mugen Terzioglu Liliya Euro Anu Suomalainen
author_sort	Olesia Ignatenko
title	Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
title_short	Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
title_full	Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
title_fullStr	Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
title_full_unstemmed	Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
title_sort	loss of mtdna activates astrocytes and leads to spongiotic encephalopathy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8d59af2ffbf5490da6e60f5f6221a5f0
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Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

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