Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.

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Autores principales: Olesia Ignatenko, Dmitri Chilov, Ilse Paetau, Elena de Miguel, Christopher B. Jackson, Gabrielle Capin, Anders Paetau, Mugen Terzioglu, Liliya Euro, Anu Suomalainen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8d59af2ffbf5490da6e60f5f6221a5f0
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