Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

BackgroundSomatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline. Citrullinated peptides are presented on MHC class II (MHCII) vi...

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Autores principales: Peter Symonds, Ana Marcu, Katherine W. Cook, Rachael L. Metheringham, Lindy G. Durrant, Victoria A. Brentville
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
CD4 T cell
citrulline
cancer immunotherapy
peptide elution
post-translational modification (PTM)
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/8d5be1d313284a328beb0b98f993d8fc
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