A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese

Liza S Köster,1 Robert M Kirberger2 1Section of Medicine, Department of Clinical Sciences, Integrative Mammalian Research (IMR) Center, Ross University School of Veterinary Medicine (RUSVM), Basseterre, St Kitts, West Indies; 2Diagnostic Imaging Section, Department of Companion Animal Clini...

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Autores principales:	Köster LS, Kirberger RM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	computed tomography interstitial lung disease Pekingese pulmonary hypertension. Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/8d5dcca10f4242969fca5c3c4f970784
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spelling	oai:doaj.org-article:8d5dcca10f4242969fca5c3c4f9707842021-12-02T05:12:11ZA syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese2230-2034https://doaj.org/article/8d5dcca10f4242969fca5c3c4f9707842016-02-01T00:00:00Zhttps://www.dovepress.com/a-syndrome-of-severe-idiopathic-pulmonary-parenchymal-disease-with-pul-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Liza S Köster,1 Robert M Kirberger2 1Section of Medicine, Department of Clinical Sciences, Integrative Mammalian Research (IMR) Center, Ross University School of Veterinary Medicine (RUSVM), Basseterre, St Kitts, West Indies; 2Diagnostic Imaging Section, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa Abstract: This paper describes 35 Pekingese dogs with a syndrome characterized by dyspnea, cyanosis, episodic syncope, soft pulmonary “Velcro” crackles, pulmonary hypertension (PH), and computed tomography and radiographic changes consistent with pulmonary parenchymal disease. The medical data base was searched with the criteria “Pekingese” and “syncope” or “dyspnea” or “tachypnea” or “pulmonary hypertension”, over a 36-month period. Inclusion criteria were echocardiographic changes consistent with noninvasive diagnosis of PH, either subjectively by B-mode or objectively by Doppler. Dogs were excluded (n=106) if there were insufficient or poor-quality radiographic or echocardiographic records or if diseases other than chronic pulmonary disease were found to be the etiology. The records of 35 dogs met these criteria and presented with a respiratory crises preceded by a history of chronic exercise intolerance and episodic syncope. The average age was 14.5 years (range: 7–19 years), with 21 males and 14 females. Most of the dogs had an interstitial lung pattern with radiographic evidence of right heart enlargement. There was a 77% (n=27) mortality and a median survival of 60 days (interquartile range: 9–210 days). This study highlights a cor pulmonale syndrome from PH due to chronic pulmonary parenchymal disease, with a grave prognosis, in middle-aged to geriatric population of Hong Kong Pekingese. Keywords: computed tomography, interstitial lung disease, dog, syncopeKöster LSKirberger RMDove Medical Pressarticlecomputed tomographyinterstitial lung diseasePekingesepulmonary hypertension.Veterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2016, Iss Issue 1, Pp 19-31 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	computed tomography interstitial lung disease Pekingese pulmonary hypertension. Veterinary medicine SF600-1100
spellingShingle	computed tomography interstitial lung disease Pekingese pulmonary hypertension. Veterinary medicine SF600-1100 Köster LS Kirberger RM A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
description	Liza S Köster,1 Robert M Kirberger2 1Section of Medicine, Department of Clinical Sciences, Integrative Mammalian Research (IMR) Center, Ross University School of Veterinary Medicine (RUSVM), Basseterre, St Kitts, West Indies; 2Diagnostic Imaging Section, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa Abstract: This paper describes 35 Pekingese dogs with a syndrome characterized by dyspnea, cyanosis, episodic syncope, soft pulmonary “Velcro” crackles, pulmonary hypertension (PH), and computed tomography and radiographic changes consistent with pulmonary parenchymal disease. The medical data base was searched with the criteria “Pekingese” and “syncope” or “dyspnea” or “tachypnea” or “pulmonary hypertension”, over a 36-month period. Inclusion criteria were echocardiographic changes consistent with noninvasive diagnosis of PH, either subjectively by B-mode or objectively by Doppler. Dogs were excluded (n=106) if there were insufficient or poor-quality radiographic or echocardiographic records or if diseases other than chronic pulmonary disease were found to be the etiology. The records of 35 dogs met these criteria and presented with a respiratory crises preceded by a history of chronic exercise intolerance and episodic syncope. The average age was 14.5 years (range: 7–19 years), with 21 males and 14 females. Most of the dogs had an interstitial lung pattern with radiographic evidence of right heart enlargement. There was a 77% (n=27) mortality and a median survival of 60 days (interquartile range: 9–210 days). This study highlights a cor pulmonale syndrome from PH due to chronic pulmonary parenchymal disease, with a grave prognosis, in middle-aged to geriatric population of Hong Kong Pekingese. Keywords: computed tomography, interstitial lung disease, dog, syncope
format	article
author	Köster LS Kirberger RM
author_facet	Köster LS Kirberger RM
author_sort	Köster LS
title	A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_short	A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_full	A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_fullStr	A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_full_unstemmed	A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese
title_sort	syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in pekingese
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8d5dcca10f4242969fca5c3c4f970784
work_keys_str_mv	AT kosterls asyndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese AT kirbergerrm asyndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese AT kosterls syndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese AT kirbergerrm syndromeofsevereidiopathicpulmonaryparenchymaldiseasewithpulmonaryhypertensioninpekingese
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A syndrome of severe idiopathic pulmonary parenchymal disease with pulmonary hypertension in Pekingese

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