Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.
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Nature Portfolio
2020
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oai:doaj.org-article:8d60e15645a540748f0978aece6a6bc52021-12-02T15:37:15ZOncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation10.1038/s41467-020-15497-12041-1723https://doaj.org/article/8d60e15645a540748f0978aece6a6bc52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15497-1https://doaj.org/toc/2041-1723Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.Shaima’a HamarshehLena OsswaldBenedikt S. SallerSusanne UngerDonatella De FeoJanaki Manoja VinnakotaMartina KonantzFranziska M. UhlHeiko BeckerMichael LübbertKhalid ShoumariyehChristoph SchürchGeoffroy AndrieuxNils VenhoffAnnette Schmitt-GraeffSandra DuquesneDietmar PfeiferMatthew A. CooperClaudia LengerkeMelanie BoerriesJustus DuysterCharlotte M. NiemeyerMiriam ErlacherBruce R. BlazarBurkard BecherOlaf GroßTilman BrummerRobert ZeiserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Shaima’a Hamarsheh Lena Osswald Benedikt S. Saller Susanne Unger Donatella De Feo Janaki Manoja Vinnakota Martina Konantz Franziska M. Uhl Heiko Becker Michael Lübbert Khalid Shoumariyeh Christoph Schürch Geoffroy Andrieux Nils Venhoff Annette Schmitt-Graeff Sandra Duquesne Dietmar Pfeifer Matthew A. Cooper Claudia Lengerke Melanie Boerries Justus Duyster Charlotte M. Niemeyer Miriam Erlacher Bruce R. Blazar Burkard Becher Olaf Groß Tilman Brummer Robert Zeiser Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation |
| description |
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade. |
| format |
article |
| author |
Shaima’a Hamarsheh Lena Osswald Benedikt S. Saller Susanne Unger Donatella De Feo Janaki Manoja Vinnakota Martina Konantz Franziska M. Uhl Heiko Becker Michael Lübbert Khalid Shoumariyeh Christoph Schürch Geoffroy Andrieux Nils Venhoff Annette Schmitt-Graeff Sandra Duquesne Dietmar Pfeifer Matthew A. Cooper Claudia Lengerke Melanie Boerries Justus Duyster Charlotte M. Niemeyer Miriam Erlacher Bruce R. Blazar Burkard Becher Olaf Groß Tilman Brummer Robert Zeiser |
| author_facet |
Shaima’a Hamarsheh Lena Osswald Benedikt S. Saller Susanne Unger Donatella De Feo Janaki Manoja Vinnakota Martina Konantz Franziska M. Uhl Heiko Becker Michael Lübbert Khalid Shoumariyeh Christoph Schürch Geoffroy Andrieux Nils Venhoff Annette Schmitt-Graeff Sandra Duquesne Dietmar Pfeifer Matthew A. Cooper Claudia Lengerke Melanie Boerries Justus Duyster Charlotte M. Niemeyer Miriam Erlacher Bruce R. Blazar Burkard Becher Olaf Groß Tilman Brummer Robert Zeiser |
| author_sort |
Shaima’a Hamarsheh |
| title |
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation |
| title_short |
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation |
| title_full |
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation |
| title_fullStr |
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation |
| title_full_unstemmed |
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation |
| title_sort |
oncogenic krasg12d causes myeloproliferation via nlrp3 inflammasome activation |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5 |
| work_keys_str_mv |
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