Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.

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Detalles Bibliográficos
Autores principales: Aran Singanayagam, Nicholas Glanville, Jason L. Girkin, Yee Man Ching, Andrea Marcellini, James D. Porter, Marie Toussaint, Ross P. Walton, Lydia J. Finney, Julia Aniscenko, Jie Zhu, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Chris Grainge, Su-Ling Loo, Punnam Chander Veerati, Prabuddha S. Pathinayake, Kristy S. Nichol, Andrew T. Reid, Phillip L. James, Roberto Solari, Peter A. B. Wark, Darryl A. Knight, Miriam F. Moffatt, William O. Cookson, Michael R. Edwards, Patrick Mallia, Nathan W. Bartlett, Sebastian L. Johnston
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/8d63530adb10416897e7c8b0db9afbdb
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Descripción
Sumario:Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.

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