Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.

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Autores principales: Aran Singanayagam, Nicholas Glanville, Jason L. Girkin, Yee Man Ching, Andrea Marcellini, James D. Porter, Marie Toussaint, Ross P. Walton, Lydia J. Finney, Julia Aniscenko, Jie Zhu, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Chris Grainge, Su-Ling Loo, Punnam Chander Veerati, Prabuddha S. Pathinayake, Kristy S. Nichol, Andrew T. Reid, Phillip L. James, Roberto Solari, Peter A. B. Wark, Darryl A. Knight, Miriam F. Moffatt, William O. Cookson, Michael R. Edwards, Patrick Mallia, Nathan W. Bartlett, Sebastian L. Johnston
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8d63530adb10416897e7c8b0db9afbdb
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spelling oai:doaj.org-article:8d63530adb10416897e7c8b0db9afbdb2021-12-02T16:49:31ZCorticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations10.1038/s41467-018-04574-12041-1723https://doaj.org/article/8d63530adb10416897e7c8b0db9afbdb2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04574-1https://doaj.org/toc/2041-1723Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.Aran SinganayagamNicholas GlanvilleJason L. GirkinYee Man ChingAndrea MarcelliniJames D. PorterMarie ToussaintRoss P. WaltonLydia J. FinneyJulia AniscenkoJie ZhuMaria-Belen Trujillo-TorralboMaria Adelaide CalderazzoChris GraingeSu-Ling LooPunnam Chander VeeratiPrabuddha S. PathinayakeKristy S. NicholAndrew T. ReidPhillip L. JamesRoberto SolariPeter A. B. WarkDarryl A. KnightMiriam F. MoffattWilliam O. CooksonMichael R. EdwardsPatrick MalliaNathan W. BartlettSebastian L. JohnstonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aran Singanayagam
Nicholas Glanville
Jason L. Girkin
Yee Man Ching
Andrea Marcellini
James D. Porter
Marie Toussaint
Ross P. Walton
Lydia J. Finney
Julia Aniscenko
Jie Zhu
Maria-Belen Trujillo-Torralbo
Maria Adelaide Calderazzo
Chris Grainge
Su-Ling Loo
Punnam Chander Veerati
Prabuddha S. Pathinayake
Kristy S. Nichol
Andrew T. Reid
Phillip L. James
Roberto Solari
Peter A. B. Wark
Darryl A. Knight
Miriam F. Moffatt
William O. Cookson
Michael R. Edwards
Patrick Mallia
Nathan W. Bartlett
Sebastian L. Johnston
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
description Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.
format article
author Aran Singanayagam
Nicholas Glanville
Jason L. Girkin
Yee Man Ching
Andrea Marcellini
James D. Porter
Marie Toussaint
Ross P. Walton
Lydia J. Finney
Julia Aniscenko
Jie Zhu
Maria-Belen Trujillo-Torralbo
Maria Adelaide Calderazzo
Chris Grainge
Su-Ling Loo
Punnam Chander Veerati
Prabuddha S. Pathinayake
Kristy S. Nichol
Andrew T. Reid
Phillip L. James
Roberto Solari
Peter A. B. Wark
Darryl A. Knight
Miriam F. Moffatt
William O. Cookson
Michael R. Edwards
Patrick Mallia
Nathan W. Bartlett
Sebastian L. Johnston
author_facet Aran Singanayagam
Nicholas Glanville
Jason L. Girkin
Yee Man Ching
Andrea Marcellini
James D. Porter
Marie Toussaint
Ross P. Walton
Lydia J. Finney
Julia Aniscenko
Jie Zhu
Maria-Belen Trujillo-Torralbo
Maria Adelaide Calderazzo
Chris Grainge
Su-Ling Loo
Punnam Chander Veerati
Prabuddha S. Pathinayake
Kristy S. Nichol
Andrew T. Reid
Phillip L. James
Roberto Solari
Peter A. B. Wark
Darryl A. Knight
Miriam F. Moffatt
William O. Cookson
Michael R. Edwards
Patrick Mallia
Nathan W. Bartlett
Sebastian L. Johnston
author_sort Aran Singanayagam
title Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
title_short Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
title_full Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
title_fullStr Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
title_full_unstemmed Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
title_sort corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in copd exacerbations
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8d63530adb10416897e7c8b0db9afbdb
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