Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy.
<h4>Background</h4>The autonomic nervous system plays a central role in the functioning of systems critical for the homeostasis maintenance. However, its role in the cardiovascular adaptation to pregnancy-related demands is poorly understood. We explored the maternal cardiovascular syste...
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oai:doaj.org-article:8d672733925941209e8562336d2eb36d2021-11-18T07:50:25ZPhase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy.1932-620310.1371/journal.pone.0060675https://doaj.org/article/8d672733925941209e8562336d2eb36d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23577144/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The autonomic nervous system plays a central role in the functioning of systems critical for the homeostasis maintenance. However, its role in the cardiovascular adaptation to pregnancy-related demands is poorly understood. We explored the maternal cardiovascular systems throughout pregnancy to quantify pregnancy-related autonomic nervous system adaptations.<h4>Methodology</h4>Continuous monitoring of heart rate (R-R interval; derived from the 3-lead electrocardiography), blood pressure, and thoracic impedance was carried out in thirty-six women at six time-points throughout pregnancy. In order to quantify in addition to the longitudinal effects on baseline levels throughout gestation the immediate adaptive heart rate and blood pressure changes at each time point, a simple reflex test, deep breathing, was applied. Consequently, heart rate variability and blood pressure variability in the low (LF) and high (HF) frequency range, respiration and baroreceptor sensitivity were analyzed in resting conditions and after deep breathing. The adjustment of the rhythms of the R-R interval, blood pressure and respiration partitioned for the sympathetic and the parasympathetic branch of the autonomic nervous system were quantified by the phase synchronization index γ, which has been adopted from the analysis of weakly coupled chaotic oscillators.<h4>Results</h4>Heart rate and LF/HF ratio increased throughout pregnancy and these effects were accompanied by a continuous loss of baroreceptor sensitivity. The increases in heart rate and LF/HF ratio levels were associated with an increasing decline in the ability to flexibly respond to additional demands (i.e., diminished adaptive responses to deep breathing). The phase synchronization index γ showed that the observed effects could be explained by a decreased coupling of respiration and the cardiovascular system (HF components of heart rate and blood pressure).<h4>Conclusions/significance</h4>The findings suggest that during the course of pregnancy the individual systems become increasingly independent to meet the increasing demands placed on the maternal cardiovascular and respiratory system.Manfred Georg MoertlHelmut Karl LacknerIlona PapousekAndreas RoesslerHelmut Hinghofer-SzalkayUwe LangVassiliki Kolovetsiou-KreinerDietmar SchlembachPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60675 (2013) |
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Medicine R Science Q Manfred Georg Moertl Helmut Karl Lackner Ilona Papousek Andreas Roessler Helmut Hinghofer-Szalkay Uwe Lang Vassiliki Kolovetsiou-Kreiner Dietmar Schlembach Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| description |
<h4>Background</h4>The autonomic nervous system plays a central role in the functioning of systems critical for the homeostasis maintenance. However, its role in the cardiovascular adaptation to pregnancy-related demands is poorly understood. We explored the maternal cardiovascular systems throughout pregnancy to quantify pregnancy-related autonomic nervous system adaptations.<h4>Methodology</h4>Continuous monitoring of heart rate (R-R interval; derived from the 3-lead electrocardiography), blood pressure, and thoracic impedance was carried out in thirty-six women at six time-points throughout pregnancy. In order to quantify in addition to the longitudinal effects on baseline levels throughout gestation the immediate adaptive heart rate and blood pressure changes at each time point, a simple reflex test, deep breathing, was applied. Consequently, heart rate variability and blood pressure variability in the low (LF) and high (HF) frequency range, respiration and baroreceptor sensitivity were analyzed in resting conditions and after deep breathing. The adjustment of the rhythms of the R-R interval, blood pressure and respiration partitioned for the sympathetic and the parasympathetic branch of the autonomic nervous system were quantified by the phase synchronization index γ, which has been adopted from the analysis of weakly coupled chaotic oscillators.<h4>Results</h4>Heart rate and LF/HF ratio increased throughout pregnancy and these effects were accompanied by a continuous loss of baroreceptor sensitivity. The increases in heart rate and LF/HF ratio levels were associated with an increasing decline in the ability to flexibly respond to additional demands (i.e., diminished adaptive responses to deep breathing). The phase synchronization index γ showed that the observed effects could be explained by a decreased coupling of respiration and the cardiovascular system (HF components of heart rate and blood pressure).<h4>Conclusions/significance</h4>The findings suggest that during the course of pregnancy the individual systems become increasingly independent to meet the increasing demands placed on the maternal cardiovascular and respiratory system. |
| format |
article |
| author |
Manfred Georg Moertl Helmut Karl Lackner Ilona Papousek Andreas Roessler Helmut Hinghofer-Szalkay Uwe Lang Vassiliki Kolovetsiou-Kreiner Dietmar Schlembach |
| author_facet |
Manfred Georg Moertl Helmut Karl Lackner Ilona Papousek Andreas Roessler Helmut Hinghofer-Szalkay Uwe Lang Vassiliki Kolovetsiou-Kreiner Dietmar Schlembach |
| author_sort |
Manfred Georg Moertl |
| title |
Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| title_short |
Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| title_full |
Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| title_fullStr |
Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| title_full_unstemmed |
Phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| title_sort |
phase synchronization of hemodynamic variables at rest and after deep breathing measured during the course of pregnancy. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/8d672733925941209e8562336d2eb36d |
| work_keys_str_mv |
AT manfredgeorgmoertl phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT helmutkarllackner phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT ilonapapousek phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT andreasroessler phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT helmuthinghoferszalkay phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT uwelang phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT vassilikikolovetsioukreiner phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy AT dietmarschlembach phasesynchronizationofhemodynamicvariablesatrestandafterdeepbreathingmeasuredduringthecourseofpregnancy |
| _version_ |
1718422867060719616 |