Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)

The incidence and mortality rate of C. difficile infection (CDI) has increased remarkably over the last 10-20 years. CDI is a leading cause of healthcare-associated infections and antibiotic-associated diarrhoea. Increasing incidence and severity of CDI may be related with frequent antibiotic use an...

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Autores principales:	I. V. Nikolaeva, I. V. Shestakova, G. K. Murtazina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	clostridium difficile antibiotic-associated diarrhea pseudomembranous colitis Science Q
Acceso en línea:	https://doaj.org/article/8d67caa2569e4b6f96edc299b5d9b79e
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spelling	oai:doaj.org-article:8d67caa2569e4b6f96edc299b5d9b79e2021-11-23T06:14:39ZCurrent strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)2541-94202587-959610.29413/ABS.2018-3.1.5https://doaj.org/article/8d67caa2569e4b6f96edc299b5d9b79e2018-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/534https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The incidence and mortality rate of C. difficile infection (CDI) has increased remarkably over the last 10-20 years. CDI is a leading cause of healthcare-associated infections and antibiotic-associated diarrhoea. Increasing incidence and severity of CDI may be related with frequent antibiotic use and the emergence of a hypervirulent C. difficile strain. The epidemic strain NAP1 / BI / ribotype 027 is more resistant to antibiotics and produces more toxins and causes outbreaks around the world with increasing mortality and severity. Recent reports have documented that C. difficile infections occur among patients without traditional risk factors and the incidence of community-acquired CDI has increased. The clinical presentation of CDI ranging from the asymptomatic carrier to pseudomembranous colitis and toxic megacolon. The rate of recurrent CDI is 20-30 %. Early surgical consultation should be considered in all patients with severe or fulminant CDI. The preferred method for diagnosis CDI is stool testing using enzyme immunoassay (EIA) screening to look for glutamate dehydrogenase (GDH) antigen and toxins A and B. Metronidazole and vancomycin are recommended antibiotics for the treatment of CDI. Novel approaches include fidaxomicin therapy, monoclonal antibodies, and fecal microbiota transplantation. Fecal microbiota transplantation has shown relevant efficacy to overcome C. difficile infection and reduce it.I. V. NikolaevaI. V. ShestakovaG. K. MurtazinaScientific Сentre for Family Health and Human Reproduction Problemsarticleclostridium difficileclostridium difficileantibiotic-associated diarrheapseudomembranous colitisScienceQRUActa Biomedica Scientifica, Vol 3, Iss 1, Pp 34-42 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	clostridium difficile clostridium difficile antibiotic-associated diarrhea pseudomembranous colitis Science Q
spellingShingle	clostridium difficile clostridium difficile antibiotic-associated diarrhea pseudomembranous colitis Science Q I. V. Nikolaeva I. V. Shestakova G. K. Murtazina Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)
description	The incidence and mortality rate of C. difficile infection (CDI) has increased remarkably over the last 10-20 years. CDI is a leading cause of healthcare-associated infections and antibiotic-associated diarrhoea. Increasing incidence and severity of CDI may be related with frequent antibiotic use and the emergence of a hypervirulent C. difficile strain. The epidemic strain NAP1 / BI / ribotype 027 is more resistant to antibiotics and produces more toxins and causes outbreaks around the world with increasing mortality and severity. Recent reports have documented that C. difficile infections occur among patients without traditional risk factors and the incidence of community-acquired CDI has increased. The clinical presentation of CDI ranging from the asymptomatic carrier to pseudomembranous colitis and toxic megacolon. The rate of recurrent CDI is 20-30 %. Early surgical consultation should be considered in all patients with severe or fulminant CDI. The preferred method for diagnosis CDI is stool testing using enzyme immunoassay (EIA) screening to look for glutamate dehydrogenase (GDH) antigen and toxins A and B. Metronidazole and vancomycin are recommended antibiotics for the treatment of CDI. Novel approaches include fidaxomicin therapy, monoclonal antibodies, and fecal microbiota transplantation. Fecal microbiota transplantation has shown relevant efficacy to overcome C. difficile infection and reduce it.
format	article
author	I. V. Nikolaeva I. V. Shestakova G. K. Murtazina
author_facet	I. V. Nikolaeva I. V. Shestakova G. K. Murtazina
author_sort	I. V. Nikolaeva
title	Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)
title_short	Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)
title_full	Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)
title_fullStr	Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)
title_full_unstemmed	Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)
title_sort	current strategies for diagnosis and treatment of clostridium difficile-infection (literature review)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/8d67caa2569e4b6f96edc299b5d9b79e
work_keys_str_mv	AT ivnikolaeva currentstrategiesfordiagnosisandtreatmentofclostridiumdifficileinfectionliteraturereview AT ivshestakova currentstrategiesfordiagnosisandtreatmentofclostridiumdifficileinfectionliteraturereview AT gkmurtazina currentstrategiesfordiagnosisandtreatmentofclostridiumdifficileinfectionliteraturereview
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Current strategies for diagnosis and treatment of Clostridium difficile-infection (literature review)

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