KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.

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Autores principales:	Michal Lipinski, Rafael Muñoz-Viana, Beatriz del Blanco, Angel Marquez-Galera, Juan Medrano-Relinque, José M. Caramés, Andrzej A. Szczepankiewicz, Jordi Fernandez-Albert, Carmen M. Navarrón, Roman Olivares, Grzegorz M. Wilczyński, Santiago Canals, Jose P. Lopez-Atalaya, Angel Barco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d6aa25253f747418d7750e6dad126ba
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spelling	oai:doaj.org-article:8d6aa25253f747418d7750e6dad126ba2021-12-02T15:45:24ZKAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain10.1038/s41467-020-16246-02041-1723https://doaj.org/article/8d6aa25253f747418d7750e6dad126ba2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16246-0https://doaj.org/toc/2041-1723Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.Michal LipinskiRafael Muñoz-VianaBeatriz del BlancoAngel Marquez-GaleraJuan Medrano-RelinqueJosé M. CaramésAndrzej A. SzczepankiewiczJordi Fernandez-AlbertCarmen M. NavarrónRoman OlivaresGrzegorz M. WilczyńskiSantiago CanalsJose P. Lopez-AtalayaAngel BarcoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal Lipinski Rafael Muñoz-Viana Beatriz del Blanco Angel Marquez-Galera Juan Medrano-Relinque José M. Caramés Andrzej A. Szczepankiewicz Jordi Fernandez-Albert Carmen M. Navarrón Roman Olivares Grzegorz M. Wilczyński Santiago Canals Jose P. Lopez-Atalaya Angel Barco KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
description	Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.
format	article
author	Michal Lipinski Rafael Muñoz-Viana Beatriz del Blanco Angel Marquez-Galera Juan Medrano-Relinque José M. Caramés Andrzej A. Szczepankiewicz Jordi Fernandez-Albert Carmen M. Navarrón Roman Olivares Grzegorz M. Wilczyński Santiago Canals Jose P. Lopez-Atalaya Angel Barco
author_facet	Michal Lipinski Rafael Muñoz-Viana Beatriz del Blanco Angel Marquez-Galera Juan Medrano-Relinque José M. Caramés Andrzej A. Szczepankiewicz Jordi Fernandez-Albert Carmen M. Navarrón Roman Olivares Grzegorz M. Wilczyński Santiago Canals Jose P. Lopez-Atalaya Angel Barco
author_sort	Michal Lipinski
title	KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
title_short	KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
title_full	KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
title_fullStr	KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
title_full_unstemmed	KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
title_sort	kat3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d6aa25253f747418d7750e6dad126ba
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KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

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