Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for over 50 days, involving MSC secretome proteins, A...

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Autores principales:	Doan C. Nguyen, Swetha Garimalla, Haopeng Xiao, Shuya Kyu, Igor Albizua, Jacques Galipeau, Kuang-Yueh Chiang, Edmund K. Waller, Ronghu Wu, Greg Gibson, James Roberson, Frances E. Lund, Troy D. Randall, Iñaki Sanz, F. Eun-Hyung Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d6c5b762cbe4e5192797c6d2043c3fe
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spelling	oai:doaj.org-article:8d6c5b762cbe4e5192797c6d2043c3fe2021-12-02T14:39:45ZFactors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion10.1038/s41467-018-05853-72041-1723https://doaj.org/article/8d6c5b762cbe4e5192797c6d2043c3fe2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05853-7https://doaj.org/toc/2041-1723Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for over 50 days, involving MSC secretome proteins, APRIL, and hypoxic conditions.Doan C. NguyenSwetha GarimallaHaopeng XiaoShuya KyuIgor AlbizuaJacques GalipeauKuang-Yueh ChiangEdmund K. WallerRonghu WuGreg GibsonJames RobersonFrances E. LundTroy D. RandallIñaki SanzF. Eun-Hyung LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Doan C. Nguyen Swetha Garimalla Haopeng Xiao Shuya Kyu Igor Albizua Jacques Galipeau Kuang-Yueh Chiang Edmund K. Waller Ronghu Wu Greg Gibson James Roberson Frances E. Lund Troy D. Randall Iñaki Sanz F. Eun-Hyung Lee Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
description	Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for over 50 days, involving MSC secretome proteins, APRIL, and hypoxic conditions.
format	article
author	Doan C. Nguyen Swetha Garimalla Haopeng Xiao Shuya Kyu Igor Albizua Jacques Galipeau Kuang-Yueh Chiang Edmund K. Waller Ronghu Wu Greg Gibson James Roberson Frances E. Lund Troy D. Randall Iñaki Sanz F. Eun-Hyung Lee
author_facet	Doan C. Nguyen Swetha Garimalla Haopeng Xiao Shuya Kyu Igor Albizua Jacques Galipeau Kuang-Yueh Chiang Edmund K. Waller Ronghu Wu Greg Gibson James Roberson Frances E. Lund Troy D. Randall Iñaki Sanz F. Eun-Hyung Lee
author_sort	Doan C. Nguyen
title	Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
title_short	Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
title_full	Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
title_fullStr	Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
title_full_unstemmed	Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
title_sort	factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8d6c5b762cbe4e5192797c6d2043c3fe
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Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

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