Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

By analyzing tissue from non-human primates with or without heart failure and in vitro methods, Liu et al. demonstrate that amylin deposition in heart failure contributes to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. Their study demonstrates the pathological role of amylin and...

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Autores principales: Miao Liu, Nan Li, Chun Qu, Yilin Gao, Lijie Wu, Liangbiao George Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8d6ea06d943b483fbab204845dae3856
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Sumario:By analyzing tissue from non-human primates with or without heart failure and in vitro methods, Liu et al. demonstrate that amylin deposition in heart failure contributes to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. Their study demonstrates the pathological role of amylin and establishes it as a target for heart disease patients.