Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

By analyzing tissue from non-human primates with or without heart failure and in vitro methods, Liu et al. demonstrate that amylin deposition in heart failure contributes to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. Their study demonstrates the pathological role of amylin and...

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Autores principales:	Miao Liu, Nan Li, Chun Qu, Yilin Gao, Lijie Wu, Liangbiao George Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8d6ea06d943b483fbab204845dae3856
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spelling	oai:doaj.org-article:8d6ea06d943b483fbab204845dae38562021-12-02T13:30:09ZAmylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates10.1038/s42003-021-01676-32399-3642https://doaj.org/article/8d6ea06d943b483fbab204845dae38562021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01676-3https://doaj.org/toc/2399-3642By analyzing tissue from non-human primates with or without heart failure and in vitro methods, Liu et al. demonstrate that amylin deposition in heart failure contributes to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. Their study demonstrates the pathological role of amylin and establishes it as a target for heart disease patients.Miao LiuNan LiChun QuYilin GaoLijie WuLiangbiao George HuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Miao Liu Nan Li Chun Qu Yilin Gao Lijie Wu Liangbiao George Hu Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
description	By analyzing tissue from non-human primates with or without heart failure and in vitro methods, Liu et al. demonstrate that amylin deposition in heart failure contributes to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling. Their study demonstrates the pathological role of amylin and establishes it as a target for heart disease patients.
format	article
author	Miao Liu Nan Li Chun Qu Yilin Gao Lijie Wu Liangbiao George Hu
author_facet	Miao Liu Nan Li Chun Qu Yilin Gao Lijie Wu Liangbiao George Hu
author_sort	Miao Liu
title	Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
title_short	Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
title_full	Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
title_fullStr	Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
title_full_unstemmed	Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates
title_sort	amylin deposition activates hif1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (pfkfb3) signaling in failing hearts of non-human primates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d6ea06d943b483fbab204845dae3856
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Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates

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