A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

The proteasome, an essential molecular machine, is a threonine protease, but the evolution and the components of its proteolytic centre are unclear. Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Eva M. Huber, Wolfgang Heinemeyer, Xia Li, Cassandra S. Arendt, Mark Hochstrasser, Michael Groll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d736013f95044c8b26f6406a2319c6e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8d736013f95044c8b26f6406a2319c6e
record_format	dspace
spelling	oai:doaj.org-article:8d736013f95044c8b26f6406a2319c6e2021-12-02T14:39:35ZA unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome10.1038/ncomms109002041-1723https://doaj.org/article/8d736013f95044c8b26f6406a2319c6e2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10900https://doaj.org/toc/2041-1723The proteasome, an essential molecular machine, is a threonine protease, but the evolution and the components of its proteolytic centre are unclear. Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity.Eva M. HuberWolfgang HeinemeyerXia LiCassandra S. ArendtMark HochstrasserMichael GrollNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eva M. Huber Wolfgang Heinemeyer Xia Li Cassandra S. Arendt Mark Hochstrasser Michael Groll A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
description	The proteasome, an essential molecular machine, is a threonine protease, but the evolution and the components of its proteolytic centre are unclear. Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity.
format	article
author	Eva M. Huber Wolfgang Heinemeyer Xia Li Cassandra S. Arendt Mark Hochstrasser Michael Groll
author_facet	Eva M. Huber Wolfgang Heinemeyer Xia Li Cassandra S. Arendt Mark Hochstrasser Michael Groll
author_sort	Eva M. Huber
title	A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
title_short	A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
title_full	A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
title_fullStr	A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
title_full_unstemmed	A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
title_sort	unified mechanism for proteolysis and autocatalytic activation in the 20s proteasome
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8d736013f95044c8b26f6406a2319c6e
work_keys_str_mv	AT evamhuber aunifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT wolfgangheinemeyer aunifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT xiali aunifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT cassandrasarendt aunifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT markhochstrasser aunifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT michaelgroll aunifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT evamhuber unifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT wolfgangheinemeyer unifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT xiali unifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT cassandrasarendt unifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT markhochstrasser unifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome AT michaelgroll unifiedmechanismforproteolysisandautocatalyticactivationinthe20sproteasome
_version_	1718390603386978304

A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

Ejemplares similares