A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome

The proteasome, an essential molecular machine, is a threonine protease, but the evolution and the components of its proteolytic centre are unclear. Here, the authors use structural biology and biochemistry to investigate the role of proteasome active site residues on maturation and activity.

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Autores principales: Eva M. Huber, Wolfgang Heinemeyer, Xia Li, Cassandra S. Arendt, Mark Hochstrasser, Michael Groll
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/8d736013f95044c8b26f6406a2319c6e
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