Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.

<h4>Background</h4>Studies suggested that the inter-individual differences in metabolizing isoflavone daidzein to equol or O-desmethylangolensin (ODMA) might explain the inconsistency of the soy/isoflavones efficacy on cardiovascular health.<h4>Objectives</h4>The study aims t...

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Autores principales:	Zhao-min Liu, Suzanne C Ho, Yu-ming Chen, Jun Liu, Jean Woo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d754ff135714cd79f821c32e2832ef1
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spelling	oai:doaj.org-article:8d754ff135714cd79f821c32e2832ef12021-11-18T08:32:52ZCardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.1932-620310.1371/journal.pone.0087861https://doaj.org/article/8d754ff135714cd79f821c32e2832ef12014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24533060/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Studies suggested that the inter-individual differences in metabolizing isoflavone daidzein to equol or O-desmethylangolensin (ODMA) might explain the inconsistency of the soy/isoflavones efficacy on cardiovascular health.<h4>Objectives</h4>The study aims to evaluate the relationship between equol and ODMA phenotypes and cardiovascular risks with habitual isoflavone consumption in Chinese postmenopausal women.<h4>Methods</h4>This is a cross-sectional study among 726 prehypertensive postmenopal women who were screened for a randomized controlled trial. 648 women returned a daidzein-challenged urine samples for determination of equol and O-DMA production. 595 attended clinic visits for assessment of cardiovascular risks including body composition, blood pressure (BP), serum lipids, uric acid, high sensitivity C-reactive protein (hs-CRP), fasting glucose and free fatty acid (FFA).<h4>Results</h4>The prevalences of equol and O-DMA producers were 53.2% and 60.9% respectively. Equol producers had higher fat free mass (p = 0.001), lower systolic (p = 0.01) and diastolic (p = 0.01) BP, serum triglyceride (p = 0.023), hs-CRP (p = 0.015) and FFA (p = 0.001) than non-producers. O-DMA producers had lower body fat% (p = 0.032), SBP (p = 0.02), total cholesterol (p = 0.002) than non-producers. The significant differences remained after further adjustment for potential confounders. The habitual soy isoflavones intake had little relation to cardiovascular risk factors in either equol/O-DMA producer phenotypes.<h4>Conclusion</h4>Equol/O-DMA producers had more favorable cardiovascular risk profiles than non-producers in prehypertensive postmenopausal women.Zhao-min LiuSuzanne C HoYu-ming ChenJun LiuJean WooPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87861 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhao-min Liu Suzanne C Ho Yu-ming Chen Jun Liu Jean Woo Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
description	<h4>Background</h4>Studies suggested that the inter-individual differences in metabolizing isoflavone daidzein to equol or O-desmethylangolensin (ODMA) might explain the inconsistency of the soy/isoflavones efficacy on cardiovascular health.<h4>Objectives</h4>The study aims to evaluate the relationship between equol and ODMA phenotypes and cardiovascular risks with habitual isoflavone consumption in Chinese postmenopausal women.<h4>Methods</h4>This is a cross-sectional study among 726 prehypertensive postmenopal women who were screened for a randomized controlled trial. 648 women returned a daidzein-challenged urine samples for determination of equol and O-DMA production. 595 attended clinic visits for assessment of cardiovascular risks including body composition, blood pressure (BP), serum lipids, uric acid, high sensitivity C-reactive protein (hs-CRP), fasting glucose and free fatty acid (FFA).<h4>Results</h4>The prevalences of equol and O-DMA producers were 53.2% and 60.9% respectively. Equol producers had higher fat free mass (p = 0.001), lower systolic (p = 0.01) and diastolic (p = 0.01) BP, serum triglyceride (p = 0.023), hs-CRP (p = 0.015) and FFA (p = 0.001) than non-producers. O-DMA producers had lower body fat% (p = 0.032), SBP (p = 0.02), total cholesterol (p = 0.002) than non-producers. The significant differences remained after further adjustment for potential confounders. The habitual soy isoflavones intake had little relation to cardiovascular risk factors in either equol/O-DMA producer phenotypes.<h4>Conclusion</h4>Equol/O-DMA producers had more favorable cardiovascular risk profiles than non-producers in prehypertensive postmenopausal women.
format	article
author	Zhao-min Liu Suzanne C Ho Yu-ming Chen Jun Liu Jean Woo
author_facet	Zhao-min Liu Suzanne C Ho Yu-ming Chen Jun Liu Jean Woo
author_sort	Zhao-min Liu
title	Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
title_short	Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
title_full	Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
title_fullStr	Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
title_full_unstemmed	Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
title_sort	cardiovascular risks in relation to daidzein metabolizing phenotypes among chinese postmenopausal women.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8d754ff135714cd79f821c32e2832ef1
work_keys_str_mv	AT zhaominliu cardiovascularrisksinrelationtodaidzeinmetabolizingphenotypesamongchinesepostmenopausalwomen AT suzannecho cardiovascularrisksinrelationtodaidzeinmetabolizingphenotypesamongchinesepostmenopausalwomen AT yumingchen cardiovascularrisksinrelationtodaidzeinmetabolizingphenotypesamongchinesepostmenopausalwomen AT junliu cardiovascularrisksinrelationtodaidzeinmetabolizingphenotypesamongchinesepostmenopausalwomen AT jeanwoo cardiovascularrisksinrelationtodaidzeinmetabolizingphenotypesamongchinesepostmenopausalwomen
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Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.

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