Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots

The studies were carried out on white Wistar rats. The dry extract from Serratula centauroides L. was introduced to the animals at the doses of 50,100, and 150 mg/kg for 7 days prior to the testing. The nootropic effect of S. centauroides was estimated by using the test "conditioned passive avo...

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Autores principales:	I. V. Sviridov, Y. G. Razuvaeva, L. N. Shantanova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	serratula centauroides l. противосудорожная активность serratula centauroides l anticonvulsant activity nootropic activity Science Q
Acceso en línea:	https://doaj.org/article/8d783a97e4be4ed8b62a53d4a2e93e68
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spelling	oai:doaj.org-article:8d783a97e4be4ed8b62a53d4a2e93e682021-11-23T06:14:32ZNootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots2541-94202587-9596https://doaj.org/article/8d783a97e4be4ed8b62a53d4a2e93e682015-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/39https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The studies were carried out on white Wistar rats. The dry extract from Serratula centauroides L. was introduced to the animals at the doses of 50,100, and 150 mg/kg for 7 days prior to the testing. The nootropic effect of S. centauroides was estimated by using the test "conditioned passive avoidance reflex". In the groups of animals treated with the S. centauroides extract the number of animals with retained reflex was more than in the control group and the latent period of input into the dark bay of the device was longer than in the animals of the control group. The anticonvulsive activity of the S. centauroides extract was tested on the model of thiosemicarbazide-induced convulsions (30 mg/kg). It has been shown that the S. centauroides extract at the doses of 50-150 mg/kg prolongs the latent period of convulsion onset by 33% and increases the lifespan of the animals by 31-47% on the background of thiosemicarbazide-induced convulsions.I. V. SviridovY. G. RazuvaevaL. N. ShantanovaScientific Сentre for Family Health and Human Reproduction Problemsarticleserratula centauroides l. противосудорожная активностьserratula centauroides lanticonvulsant activitynootropic activityScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2, Pp 89-91 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	serratula centauroides l. противосудорожная активность serratula centauroides l anticonvulsant activity nootropic activity Science Q
spellingShingle	serratula centauroides l. противосудорожная активность serratula centauroides l anticonvulsant activity nootropic activity Science Q I. V. Sviridov Y. G. Razuvaeva L. N. Shantanova Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots
description	The studies were carried out on white Wistar rats. The dry extract from Serratula centauroides L. was introduced to the animals at the doses of 50,100, and 150 mg/kg for 7 days prior to the testing. The nootropic effect of S. centauroides was estimated by using the test "conditioned passive avoidance reflex". In the groups of animals treated with the S. centauroides extract the number of animals with retained reflex was more than in the control group and the latent period of input into the dark bay of the device was longer than in the animals of the control group. The anticonvulsive activity of the S. centauroides extract was tested on the model of thiosemicarbazide-induced convulsions (30 mg/kg). It has been shown that the S. centauroides extract at the doses of 50-150 mg/kg prolongs the latent period of convulsion onset by 33% and increases the lifespan of the animals by 31-47% on the background of thiosemicarbazide-induced convulsions.
format	article
author	I. V. Sviridov Y. G. Razuvaeva L. N. Shantanova
author_facet	I. V. Sviridov Y. G. Razuvaeva L. N. Shantanova
author_sort	I. V. Sviridov
title	Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots
title_short	Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots
title_full	Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots
title_fullStr	Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots
title_full_unstemmed	Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots
title_sort	nootropic and anticonvulsant properties of the dry extract from serratula centauroides roots
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/8d783a97e4be4ed8b62a53d4a2e93e68
work_keys_str_mv	AT ivsviridov nootropicandanticonvulsantpropertiesofthedryextractfromserratulacentauroidesroots AT ygrazuvaeva nootropicandanticonvulsantpropertiesofthedryextractfromserratulacentauroidesroots AT lnshantanova nootropicandanticonvulsantpropertiesofthedryextractfromserratulacentauroidesroots
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Nootropic and anticonvulsant properties of the dry extract from Serratula Centauroides roots

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