Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis

Abstract Melatonin has shown promising neuroprotective effects due to its anti-oxidant, anti-inflammatory and anti-apoptotic properties, making it a candidate drug for translation to humans in conditions that compromise the developing brain. Our study aimed to explore the impact of prenatal melatoni...

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Autores principales:	Geraldine Favrais, Elie Saliba, Léa Savary, Sylvie Bodard, Zuhal Gulhan, Pierre Gressens, Sylvie Chalon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d78bac2f5c146d891b78e27e7ffa07d
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spelling	oai:doaj.org-article:8d78bac2f5c146d891b78e27e7ffa07d2021-11-14T12:18:41ZPartial protective effects of melatonin on developing brain in a rat model of chorioamnionitis10.1038/s41598-021-01746-w2045-2322https://doaj.org/article/8d78bac2f5c146d891b78e27e7ffa07d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01746-whttps://doaj.org/toc/2045-2322Abstract Melatonin has shown promising neuroprotective effects due to its anti-oxidant, anti-inflammatory and anti-apoptotic properties, making it a candidate drug for translation to humans in conditions that compromise the developing brain. Our study aimed to explore the impact of prenatal melatonin in an inflammatory/infectious context on GABAergic neurons and on oligodendrocytes (OLs), key cells involved in the encephalopathy of prematurity. An inflammatory/infectious agent (LPS, 300 μg/kg) was injected intraperitoneally (i.p.) to pregnant Wistar rats at gestational day 19 and 20. Melatonin (5 mg/kg) was injected i.p. following the same schedule. Immunostainings focusing on GABAergic neurons, OL lineage and myelination were performed on pup brain sections. Melatonin succeeded in preventing the LPS-induced decrease of GABAergic neurons within the retrospenial cortex, and sustainably promoted GABAergic neurons within the dentate gyrus in the inflammatory/infectious context. However, melatonin did not effectively prevent the LPS-induced alterations on OLs and myelination. Therefore, we demonstrated that melatonin partially prevented the deleterious effects of LPS according to the cell type. The timing of exposure related to the cell maturation stage is likely to be critical to achieve an efficient action of melatonin. Furthermore, it can be speculated that melatonin exerts a modest protective effect on extremely preterm infant brains.Geraldine FavraisElie SalibaLéa SavarySylvie BodardZuhal GulhanPierre GressensSylvie ChalonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geraldine Favrais Elie Saliba Léa Savary Sylvie Bodard Zuhal Gulhan Pierre Gressens Sylvie Chalon Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
description	Abstract Melatonin has shown promising neuroprotective effects due to its anti-oxidant, anti-inflammatory and anti-apoptotic properties, making it a candidate drug for translation to humans in conditions that compromise the developing brain. Our study aimed to explore the impact of prenatal melatonin in an inflammatory/infectious context on GABAergic neurons and on oligodendrocytes (OLs), key cells involved in the encephalopathy of prematurity. An inflammatory/infectious agent (LPS, 300 μg/kg) was injected intraperitoneally (i.p.) to pregnant Wistar rats at gestational day 19 and 20. Melatonin (5 mg/kg) was injected i.p. following the same schedule. Immunostainings focusing on GABAergic neurons, OL lineage and myelination were performed on pup brain sections. Melatonin succeeded in preventing the LPS-induced decrease of GABAergic neurons within the retrospenial cortex, and sustainably promoted GABAergic neurons within the dentate gyrus in the inflammatory/infectious context. However, melatonin did not effectively prevent the LPS-induced alterations on OLs and myelination. Therefore, we demonstrated that melatonin partially prevented the deleterious effects of LPS according to the cell type. The timing of exposure related to the cell maturation stage is likely to be critical to achieve an efficient action of melatonin. Furthermore, it can be speculated that melatonin exerts a modest protective effect on extremely preterm infant brains.
format	article
author	Geraldine Favrais Elie Saliba Léa Savary Sylvie Bodard Zuhal Gulhan Pierre Gressens Sylvie Chalon
author_facet	Geraldine Favrais Elie Saliba Léa Savary Sylvie Bodard Zuhal Gulhan Pierre Gressens Sylvie Chalon
author_sort	Geraldine Favrais
title	Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
title_short	Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
title_full	Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
title_fullStr	Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
title_full_unstemmed	Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
title_sort	partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d78bac2f5c146d891b78e27e7ffa07d
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Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis

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