Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?

<h4>Background</h4>To date, few parameters have been found that can aid in patient selection and surgical strategy for eloquent area gliomas.<h4>Aims</h4>The aim of the study was to analyze preoperative and intraoperative factors that can predict functional outcome and extent...

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Autores principales:	Giannantonio Spena, Federico D'Agata, Pier Paolo Panciani, Michela Buglione di Monale, Marco Maria Fontanella
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d7bcc27bdd6458bb68800f6786b60ab
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spelling	oai:doaj.org-article:8d7bcc27bdd6458bb68800f6786b60ab2021-11-18T08:43:23ZSupratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?1932-620310.1371/journal.pone.0080916https://doaj.org/article/8d7bcc27bdd6458bb68800f6786b60ab2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24339890/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To date, few parameters have been found that can aid in patient selection and surgical strategy for eloquent area gliomas.<h4>Aims</h4>The aim of the study was to analyze preoperative and intraoperative factors that can predict functional outcome and extent of resection in eloquent area tumors.<h4>Patients and methods</h4>A retrospective analysis was conducted on 60 patients harboring supratentorial gliomas in eloquent areas undergoing awake surgery. The analysis considered clinical, neuroradiologic (morphologic), intraoperative, and postoperative factors. End-points were extent of resection (EOR) as well as functional short- and long-term outcome. Postoperatively, MRI objectively established the EOR. χ(2) analyses were used to evaluate parameters that could be predictive. Multivariate logistic regression analyses were used to evaluate the best combination to predict binary positive outcomes.<h4>Results</h4>In 90% of the cases, subcortical stimulation was positive in the margins of the surgical cavity. Postoperatively, 51% of the patients deteriorated but 90% of the patients regained their preoperative neurological score. Factors negatively affecting EOR were volume, degree of subcortical infiltration, and presence of paresis (P<0.01). Sharp margins and cystic components were more amenable to gross total resection (P<0.01). Contrast enhancement (P<0.02), higher grade (P<0.01), paresis (P<0.01), and residual tumor in the cortex (P<0.02) negatively affected long-term functional outcomes, whereas postoperative deterioration could not be predicted for any factor other than paresis. Subcortical stimulation did not correlate with deterioration, both postoperatively (P<0.08) and at follow-up (P<0.042).<h4>Conclusions</h4>Biological and morphological factors such as type of margins, volume, preoperative neurological status, cystic components, histology and the type of infiltration into the white matter must be considered when planning intraoperative mapping.Giannantonio SpenaFederico D'AgataPier Paolo PancianiMichela Buglione di MonaleMarco Maria FontanellaMarco Maria FontanellaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e80916 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giannantonio Spena Federico D'Agata Pier Paolo Panciani Michela Buglione di Monale Marco Maria Fontanella Marco Maria Fontanella Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
description	<h4>Background</h4>To date, few parameters have been found that can aid in patient selection and surgical strategy for eloquent area gliomas.<h4>Aims</h4>The aim of the study was to analyze preoperative and intraoperative factors that can predict functional outcome and extent of resection in eloquent area tumors.<h4>Patients and methods</h4>A retrospective analysis was conducted on 60 patients harboring supratentorial gliomas in eloquent areas undergoing awake surgery. The analysis considered clinical, neuroradiologic (morphologic), intraoperative, and postoperative factors. End-points were extent of resection (EOR) as well as functional short- and long-term outcome. Postoperatively, MRI objectively established the EOR. χ(2) analyses were used to evaluate parameters that could be predictive. Multivariate logistic regression analyses were used to evaluate the best combination to predict binary positive outcomes.<h4>Results</h4>In 90% of the cases, subcortical stimulation was positive in the margins of the surgical cavity. Postoperatively, 51% of the patients deteriorated but 90% of the patients regained their preoperative neurological score. Factors negatively affecting EOR were volume, degree of subcortical infiltration, and presence of paresis (P<0.01). Sharp margins and cystic components were more amenable to gross total resection (P<0.01). Contrast enhancement (P<0.02), higher grade (P<0.01), paresis (P<0.01), and residual tumor in the cortex (P<0.02) negatively affected long-term functional outcomes, whereas postoperative deterioration could not be predicted for any factor other than paresis. Subcortical stimulation did not correlate with deterioration, both postoperatively (P<0.08) and at follow-up (P<0.042).<h4>Conclusions</h4>Biological and morphological factors such as type of margins, volume, preoperative neurological status, cystic components, histology and the type of infiltration into the white matter must be considered when planning intraoperative mapping.
format	article
author	Giannantonio Spena Federico D'Agata Pier Paolo Panciani Michela Buglione di Monale Marco Maria Fontanella Marco Maria Fontanella
author_facet	Giannantonio Spena Federico D'Agata Pier Paolo Panciani Michela Buglione di Monale Marco Maria Fontanella Marco Maria Fontanella
author_sort	Giannantonio Spena
title	Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
title_short	Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
title_full	Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
title_fullStr	Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
title_full_unstemmed	Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
title_sort	supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8d7bcc27bdd6458bb68800f6786b60ab
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Supratentorial gliomas in eloquent areas: which parameters can predict functional outcome and extent of resection?

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