SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic glucose production by promoting proteasomal degradatio...

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Autores principales:	Hagoon Jang, Gha Young Lee, Christopher P. Selby, Gung Lee, Yong Geun Jeon, Jae Ho Lee, Kenneth King Yip Cheng, Paul Titchenell, Morris J. Birnbaum, Aimin Xu, Aziz Sancar, Jae Bum Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d7c5bde883440f7b735e96aacbc548c
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spelling	oai:doaj.org-article:8d7c5bde883440f7b735e96aacbc548c2021-12-02T14:38:35ZSREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding10.1038/ncomms121802041-1723https://doaj.org/article/8d7c5bde883440f7b735e96aacbc548c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12180https://doaj.org/toc/2041-1723The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic glucose production by promoting proteasomal degradation of Foxo1.Hagoon JangGha Young LeeChristopher P. SelbyGung LeeYong Geun JeonJae Ho LeeKenneth King Yip ChengPaul TitchenellMorris J. BirnbaumAimin XuAziz SancarJae Bum KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hagoon Jang Gha Young Lee Christopher P. Selby Gung Lee Yong Geun Jeon Jae Ho Lee Kenneth King Yip Cheng Paul Titchenell Morris J. Birnbaum Aimin Xu Aziz Sancar Jae Bum Kim SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
description	The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic glucose production by promoting proteasomal degradation of Foxo1.
format	article
author	Hagoon Jang Gha Young Lee Christopher P. Selby Gung Lee Yong Geun Jeon Jae Ho Lee Kenneth King Yip Cheng Paul Titchenell Morris J. Birnbaum Aimin Xu Aziz Sancar Jae Bum Kim
author_facet	Hagoon Jang Gha Young Lee Christopher P. Selby Gung Lee Yong Geun Jeon Jae Ho Lee Kenneth King Yip Cheng Paul Titchenell Morris J. Birnbaum Aimin Xu Aziz Sancar Jae Bum Kim
author_sort	Hagoon Jang
title	SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
title_short	SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
title_full	SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
title_fullStr	SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
title_full_unstemmed	SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
title_sort	srebp1c-cry1 signalling represses hepatic glucose production by promoting foxo1 degradation during refeeding
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8d7c5bde883440f7b735e96aacbc548c
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SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

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